業績リスト　|　日本大学医学部細胞分子薬理学部門

業績リスト

2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011
2010 2009 2008 2007 2006 2005 2004 2003 2002 2001
2000 1999 1998 1997 1996 1995 1994 1993 1992

2021

Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A. Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 Mar;24(3):312-325. doi: 10.1038/s41593-020-00783-4. Epub 2021 Feb 15. PMID: 33589835
Watanabe H, Kanemaru K, Hagikura K, Matsumoto T, Ayusawa M, Morioka I. Soluble factors released by dedifferentiated fat cells reduce the functional activity of iPS cell-derived cardiomyocytes. Cell Biol Int. 2021 Feb;45(2):295-304. doi: 10.1002/cbin.11487. Epub 2020 Oct 29. PMID: 33073424

2020

Kitajima N, Takikawa K, Sekiya H, Satoh K, Asanuma D, Sakamoto H, Takahashi S, Hanaoka K, Urano Y, Namiki S, Iino M, Hirose K. Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor. Elife. 2020 Jul 10;9:e57544. doi: 10.7554/eLife.57544. PMID: 32648544
Kanemaru, K.*, Suzuki, J.*, Taiko, I., and Iino, M. (*equally contributed) Red fluorescent CEPIA indicators for visualization of Ca²⁺ dynamics in mitochondria. Sci Rep. 2020 10, 2835.
Takahashi, S., Hanaoka, K., Okubo, Y., Echizen, H., Ikeno, T., Komatsu, T., Ueno, T., Hirose, K., Iino, M., Nagano, T. and Urano, Y. Rational Design of a Near-infrared Fluorescence Probe for Ca²⁺ Based on Phosphorus-substituted Rhodamines Utilizing Photoinduced Electron Transfer. Chem Asian J. Epub 2020 Jan 7. Pubmed
Yamazawa, T., Ogawa, H., Murayama, T., Yamaguchi, M., Oyamada, H., Suzuki, J., Kurebayashi, N., Kanemaru, K., Oguchi, K., Sakurai, T., Iino, M. Insights into channel modulation mechanism of RYR1 mutants using Ca²⁺ imaging and molecular dynamics. J Gen Physiol. 2020 152(1) pii: e201812235. Pubmed

2019

Okubo, Y., Hirose, K., Iino, M. Store-operated Ca²⁺ entry-dependent Ca²⁺ refilling in the endoplasmic reticulum in astrocytes. Biochem Biophys Res Commun. Epub 2019 Dec 5; 2020 Feb 19; 522(4): 1003-1008. Pubmed
Okubo, Y., Iino, M. Visualization of astrocytic intracellular Ca²⁺ mobilization. J Physiol. Epub 2019 Mar 1 Pubmed
Okubo, Y., Kanemaru, K., Suzuki, J., Kobayashi, K., Hirose, K. and Iino, M. Inositol 1,4,5-trisphosphate receptor type 2-independent Ca²⁺ release from the endoplasmic reticulum in astrocytes. GLIA 2019 67(1):113-124. Pubmed

2018

Ino, M. and Iino, M. Efficient gene transfer to myelinating Schwann cells in the rodent sciatic nerve using in vivo electroporation. Methods Mol Biol. 1791:287-292. 2018. doi: 10.1007/978-1-4939-7862-5_23.
Murayama, T., Kurebayashi, N., Ishigami-Yuasa, M., Mori, S., Suzuki, Y., Akima, R., Ogawa, H., Suzuki, J., Kanemaru, K., Oyamada, H., Kiuchi, Y., Iino, M., Kagechika, H., Sakurai, T. Efficient High-Throughput Screening by Endoplasmic Reticulum Ca²⁺ Measurement to Identify Inhibitors of Ryanodine Receptor Ca²⁺-Release Channels. Mol Pharmacol. 94:722–730, 2018. doi: 10.1124/mol.117.111468.
Murakami, T.C., Mano, T., Saikawa, S., Horiguchi, S.A., Shigeta, D., Baba, K., Sekiya, H., Shimizu, Y., Tanaka, K.F., Kiyonari, H., Iino, M., Mochizuki, H., Tainaka, K., Ueda, H.R. A three-dimensional single-cell-resolution whole-brain atlas using CUBIC-X expansion microscopy and tissue clearing. Nat Neurosci. 21:625–637, 2018. doi: 10.1038/s41593-018-0109-1.
Okubo, Y., Mikami, Y., Kanemaru, K. and Iino, M. Role of endoplasmic reticulum-mediated Ca²⁺ signaling in neuronal cell death. Antioxid Redox Signal. 29(12):1147-1157. 2018. doi: 10.1089/ars.2018.7498. Pubmed

2017

Ino, D. and Iino, M. Schwann cell mitochondria as key regulators in the development and maintenance of peripheral nerve axons. Cell. Mol. Life Sci. 2017. 74, 827–835. doi: 10.1007/s00018-016-2364-1. Pubmed

2016

Kubota, J., Mikami, Y., Kanemaru, K., Sekiya, H., Okubo, Y. and Iino, M. Whisker experience-dependent mGluR signaling maintains synaptic strength in the mouse adolescent cortex. Eur. J. Neurosci. 2016 44, 2004-2014. doi: 10.1111/ejn.13285. 2016. Pubmed
Mikami, Y., Kanemaru, K., Okubo, Y., Nakaune, T., Suzuki, J., Shibata, K., Sugiyama, H., Koyama, R., Murayama, T., Ito, A., Yamazawa, T., Ikegaya, Y., Sakurai, T., Saito, N., Kakizawa, S. and Iino, M. Nitric oxide-induced activation of the type 1 ryanodine receptor Is critical for epileptic seizure-induced neuronal cell death. EBioMedicine. 11, 253–261. doi: 10.1016/j.ebiom.2016.08.020, 2016. Pubmed
Ino, D. and Iino, M. In vivo gene transfer to Schwann cells in the rodent sciatic nerve by electroporation. J. Vis. Exp. (115): e54567, doi:10.3791/54567, 2016. Pubmed
Ino, D. and Iino, M. Schwann cell mitochondria as key regulators in the development and maintenance of peripheral nerve axons. Cell Mol Life Sci. 2016 Sep 16. [Epub ahead of print] Review. PubMed PMID: 27638763. Pubmed
Suzuki, J., Kanemaru, K. and Iino, M. Genetically Encoded Fluorescent Indicators for Organellar Calcium Imaging. Biophys J. 111, 1119–1131, doi:10.1016/j.bpj.2016.04.054, 2016. Pubmed
Murayama, T., Kurebayashi, N., Ogawa, H., Yamazawa, T., Oyamada, H., Suzuki, J., Kanemaru, K., Oguchi, K., Iino, M. and Sakurai, T. Genotype-phenotype correlations of malignant hyperthermia and central core disease mutations in the central region of the RYR1 channel. Hum Mutat. 37, 1231–1241, doi: 10.1002/humu.23072. 2016. Pubmed

2015

Okubo, Y., Suzuki, J., Kanemaru, K., Nakamura, N., Shibata, T. and Iino, M. Visualization of Ca²⁺ filling mechanisms upon synaptic inputs in the endoplasmic reticulum of cerebellar Purkinje cells. J. Neurosci. 35(48):15837-15846, 2015 Abstract
Ino, D., Sagara, H., Suzuki, J., Kanemaru, K., Okubo, Y., Iino, M. Neuronal regulation of Schwann cell mitochondrial Ca²⁺ signaling during myelination. Cell Rep. 2015 doi: 10.1016/j.celrep.2015.08.039 Article
Murayama, T., Kurebayashi, N., Yamazawa, T., Oyamada, H., Suzuki, J., Kanemaru, K., Oguchi, K., Iino, M., Sakurai, T. Divergent activity profiles of type 1 ryanodine receptor channels carrying malignant hyperthermia and central core disease mutations in the amino-terminal region. PLoS ONE 10(6): e0130606, 2015 DOI: 10.1371/journal.pone.0130606. Article

2014

Kanemaru, K., Sekiya, K., Xu, M., Satoh, K., Kitajima, N., Yoshida, K., Okubo, Y., Sasaki, T., Moritoh, S., Hasuwa, H., Mimura, M., Horikawa, K., Matsui, K., Nagai, T., Iino, M., Tanaka, K.F. In vivo visualization of subtle, transient and local activity of astrocytes using an ultrasensitive Ca²⁺ indicator. Cell Rep. 2014 doi: 10.1016/j.celrep.2014.05.056. Abstract
Suzuki, J., Kanemaru, K., Ishii, K., Ohkura, M., Okubo, Y., Iino, M. Imaging intraorganellar Ca²⁺at subcellular resolution using CEPIA. Nat. Commun. 5:4153, 2014 doi: 10.1038/ncomms5153. PubMed

2013

Kanemaru, K., Kubota, J., Sekiya, H., Hirose, K, Okubo, Y., Iino, M. Calcium-dependent N-cadherin upregulation mediates reactive astrogliosis and neuroprotection after brain injury. PNAS 110, 11612-11617, 2013. PubMed

2012

Kakizawa S, Yamazawa T, Chen Y, Ito A, Murayama T, Oyamada H, Kurebayashi N, Sato O, Watanabe M, Mori N, Oguchi K, Sakurai T, Takeshima H, Saito N and Iino M. Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function. EMBO J. 31, 417-428, 2012. PubMed

2011

Okubo Y, Kanemaru K, Iino M. Imaging of Ca²⁺ and related signaling molecules and investigation of their functions in the brain. Antioxid Redox Signal. 14, 1303-1314, 2011.PubMed
Okubo, Y. and Iino, M. Visualization of glutamate as a volume transmitter. J. Physiol. 589, 481-488, 2011.PubMed Cover

2010

Mashimo, M., Okubo, Y., Yamazawa, T., Yamasaki, M., Watanabe, M., Murayama, T. and Iino, M. Inositol 1,4,5-trisphosphate signaling maintains the activity of glutamate uptake in Bergmann glia. Eur. J. Neurosci. 32, 1668-1677, 2010. PubMed
Okubo, Y., Sekiya, H, Namiki, S, Sakamoto, H., Iinuma, S., Yamasaki, M., Watanabe, M., Hirose, K. and Iino, M. Imaging extrasynaptic glutamate dynamics in the brain. Proc. Natl. Acad. Sci. U.S.A. 107, 6526-6531, 2010. PubMed

²⁺

B-Phys. Biol. Sci.

PubMed

2009

Nakamura, N., Yamazawa, T., Okubo, Y., and Iino, M. Temporal switching and cell-to-cell variability in Ca²⁺ release activity in mammalian cells. Mol. Syst. Biol. 5:247, 2009 PumMed

2008

Kakizawa, S., Moriguchi, S., Ikeda, A., Iino, M. and Takeshima, H. Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions. Cerebellum 7, 385-391,2008.
Iino, M. Identification of new functions of Ca²⁺ release from intracellular stores in central nervous system. Biochem. Biophys. Res. Commun.369, 220-224, 2008
Yogo, T., Urano, Y., Mizushima, A., Sunahara, H., Inoue, T., Hirose, K., Iino, M., Kikuchi, K. and Nagano, T. Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer. Proc. Natl. Acad. Sci. U.S.A., 105, 28-32, 2008.

2007

Uemura, T., Kakizawa, S., Yamasaki, M., Sakimura, K., Watanabe, M., Iino, M. and Mishina, M. Regulation of long-term depression and climbing fiber territory by glutamate receptor delta2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells. J. Neurosci. 27, 12096-12108, 2007.
Kamikubo, Y., Tabata, T., Kakizawa, S., Kawakami, D., Watanabe, M., Ogura, A., Iino, M. and Kano, M. Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells. J. Physiol. 585, 549-563, 2007.
Ikeda, A., Miyazaki, T., Kakizawa, S., Okuno, Y., Tsuchiya, S., Myomoto, A., Saito, S.Y., Yamamoto, T., Yamazaki, T., Iino, M., Tsujimoto, G., Watanabe, M. and Takeshima, H. Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins. Biochem. Biophys. Res. Commun.363, 835-839, 2007.
Kina, S., Tezuka, T., Kusakawa, S., Kishimoto, Y., Kakizawa, S., Hashimoto, K., Ohsugi, M., Kiyama, Y., Horai, R., Sudo, K., Kakuta, S., Iwakura, Y., Iino, M., Kano, M., Manabe, T. and Yamamoto, T. Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term cdepression. Eur. J. Neurosci., 26, 2269-2278, 2007.
Kanemaru, K., Okubo, Y., Hirose, K. and Iino, M. Regulation of neurite growth by spontaneous Ca²⁺ oscillations in astrocytes. J. Neurosci. 27, 8957-8966, 2007. PubMed This_Week_in_The_Journal
Fujiwara, A., Kakizawa, S. and Iino, M. Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells. Neuropharmacology 52, 1663-1670, 2007.
Namiki, S., Sakamoto, H., Iinuma, S., Iino, M. and Hirose, K. Optical glutamate sensor for spatiotemporal analysis of synaptic transmission. Eur. J. Neurosci. 25, 2249-2259, 2007.
Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, H., Kano, M., Watanabe, M., Iino, M. and Takeshima, H. Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. EMBO J. 26, 1924-1933, 2007.

2006

Baba,Y., Hayashi, K., Fujii, Y., Mizushima, A., Watarai, H., Wakamori, M., Numaga, T., Mori, Y., Iino, M., Hikida, M. and Kurosaki, T. Coupling of STIM1 to store-operated Ca²⁺ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 103, 16704-16709, 2006
Hashido, M., Hayashi, K., Hirose, K. and Iino, M. Ca²⁺ lightning conveys cell-cell contact information inside the cells. EMBO Rep. 7, 1117-1123, 2006
Iino, M. Ca²⁺-dependent inositol 1,4,5-trisphosphate and nitric oxide signaling in cerebellar neurons. (Review) J. Pharmacol. Sci. 100, 538-544, 2006.
Furutani, K., Okubo, Y., Kakizawa, S. and Iino, M. Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF. Proc. Natl. Acad. Sci. U.S.A. 103, 8528-8533, 2006. PubMed 朝日新聞
Ishii, K., Hirose, K. and Iino, M. Ca²⁺ shuttling between endoplasmic reticulum and mitochondria underlying Ca²⁺ oscillations. EMBO Rep. 7, 390-396, 2006

2005

Kakizawa, S., Miyazaki, T., Yanagihara, D., Iino, M., Watanabe, M. and Kano, M. Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. Proc. Natl. Acad. Sci. U.S.A. 102, 19180-19185, 2005.
Namiki, S., Kakizawa, S., Hirose, K. and Iino, M. NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum. J. Physiol. 566, 849-863, 2005.
Hashimoto, A., Hirose, K. and Iino, M. BAD detects coincidence of G2/M Phase and growth factor deprivation to regulate apoptosis. J. Biol. Chem. 280, 26225-26232, 2005.
Ueda, H.R., Hayashi, S., Chen, W., Sano, M., Machida, M., Shigeyoshi, Y., Iino, M. and Hashimoto, S. System-level identification of transcriptional circuits underlying mammalian circadian clocks. Nat. Genet. 37, 187-192, 2005.
Yamada, A., Hirose, K., Hashimoto, A. and Iino, M. Real-time imaging of myosin II regulatory light chain phosphorylation using a new protein biosensor. Biochem. J. 385, 589-594, 2005.

2004

Okubo, Y., Kakizawa, S., Hirose, K. and Iino, M. Cross talk between metabotropic and ionotropic glutamate receptor-mediated signaling in parallel fiber-induced inositol 1,4,5-trisphosphate production in cerebellar Purkinje cells. J. Neurosci. 24, 9513-9520, 2004.
Yogo, T., Kikuchi, K., Inoue, T., Hirose, K., Iino, M. and Nagano, T. Modification of intracellular Ca²⁺ dynamics by laser inactivation of inositol 1,4,5-trisphosphate receptor using membrane-permeant probes. Chem. Biol. 11, 1053-1058, 2004.
Ueda, H.R., Chen, W., Minami, Y., Honma, S., Honma, K., Iino, M. and Hashimoto, S. Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles. Proc. Natl. Acad. Sci. U.S.A. 101, 11227-11232, 2004.
Ueda, H.R., Hayashi, S., Matsuyama, S., Yomo, T., Hashimoto, S., Kay, S.A., Hogenesch, J.B. and Iino, M. Universality and flexibility in gene expression from bacteria to human. Proc. Natl. Acad. Sci. U.S.A. 101, 3765-3769, 2004.
Shirane, D., Sugao, K., Namiki, S., Tanabe, M., Iino, M. and Hirose, K. Enzymatic production of RNAi libraries from cDNAs. Nat. Genet. 36, 190-196, 2004.
Uchino, M., Sakai, N., Kashiwagi, K., Shirai, Y., Shinohara, Y., Hirose, K., Iino, M., Yamamura, T. and Saito, N. Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by protein kinase C (PKC) blocks Ca²⁺ oscillation and oscillatory translocation of Ca²⁺-dependent PKC. J. Biol. Chem. 279, 2254-2261, 2004.

2003

Tomida, T., Hirose, K., Takizawa, A., Shibasaki, F., and Iino, M. NFAT functions as a working memory of Ca²⁺ signals in decoding Ca²⁺oscillation. EMBO J. 22, 3825-3832, 2003. More Information
Namiki, S., Tomida, T., Tanabe, M., Iino, M. and Hirose, K. Intracellular delivery of glutathione S-transferase into mammalian cells. Biochem. Biophys. Res. Commun. 305, 592-597, 2003.
Tu, H., Nosyreva, E., Miyakawa, T., Wang, Z., Mizushima, A., Iino, M., Bezprozvanny, I. Functional and biochemical analysis of the type 1 inositol (1,4,5)-trisphosphate receptor calcium sensor. Biophys. J. 85, 290-299, 2003.
Inoue, T., Kikuchi, K., Hirose, K., Iino, M., Nagano, T. Spatiotemporal laser inactivation of inositol 1,4,5-trisphosphate receptors using synthetic small-molecule probes. Chem. Biol.10, 503-509, 2003.
Eto, K., Yamashita, T., Hirose, K., Tsubamoto, Y., Ainscow, EK., Rutter, G.A., Kimura, S., Noda, M., Iino, M., Kadowaki, T. Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic b-cells. Am. J. Physiol. 2003 E262-E271, 2003.
Kakizawa, S., Yamada, K., Iino, M., Watanabe, M. and Kano, M. Effects of insulin-like growth factor I on climbing fibre synapse elimination during cerebellar development. Eur. J. Neurosci.17, 545-554, 2003.
Iino, M. Family affairs of intracellular Ca²⁺-release channels. J. Physiol. 542, 667, 2002.

2002

Nosyreva, E., Miyakawa, T., Wang, Z., Glouchankova, L., Mizushima, A., Iino, M. and Bezprozvanny, I. The high-affinity calcium-calmodulin-binding site does not play a role in the modulation of type 1 inositol 1,4,5-trisphosphate receptor function by calcium and calmodulin. Biochem. J. 365, 659-667, 2002.
Ueda, H.R., Chen, W., Adachi, A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K.-I., Suzuki, Y., Sugano, S., Iino, M., Shigeyoshi, Y. and Hashimoto, S. A transcription factor response element for gene expression during circadian night. Nature418, 534-539, 2002.
Tu, H., Miyakawa, T., Wang, Z., Glouchankova, L., Iino, M. and Bezprozvanny, I. Functional characterization of the type 1 Inositol 1,4,5-trisphosphate receptor coupling domain SII({+/-}) splice variants and the opisthotonos mutant form. Biophys. J. 82, 1995-2004, 2002.
Ueda, H.R., Matsumoto, A., Kawamura, M., Iino, M., Tanimura, T. and Hashimoto, S. Genome-wide transcriptional orchestration of circadian rhythms in drosophila. J. Biol. Chem. 277, 14048-14052, 2002.
Yamazawa, T. and Iino, M. Simultaneous imaging of Ca²⁺ signals in interstitial cells of Cajal and longitudinal smooth muscle cells during rhythmic activity in mouse ileum. J. Physiol. 538, 823-835, 2002.
Oyamada, K., Oguchi, K., Saitoh, N., Yamazawa, T., Hirose, K., Kawana, Y., Wakatsuki, K., Oguchi, K., Tagami, M., Hanaoka, K., Endo, M. and Iino, M. Novel mutations in C-terminal region of the ryanodine receptor in malignant hyperthermia patients. Jpn. J. Pharmacol. 88, 159-166, 2002.
Mori, Y., Wakamori, M., Miyakawa, T., Hermosura, M., Hara, Y., Nishida, M., Hirose, K., Mizushima, A., Kurosaki, M., Mori, E., Gotoh, K., Okada, T., Fleig, A., Penner, R., Iino, M. and Kurosaki, T. Transient receptor potential 1 regulates capacitative Ca²⁺ entry and Ca²⁺release from endoplasmic reticulum in B lymphocytes. J. Exp. Med. 195, 673-681, 2002.
Takahashi, N., Nemoto, T., Kimura, R., Tachikawa, A., Miwa, A., Okado, H., Miyashita, Y., Iino, M., Kadowaki, T. and Kasai, H. Two-photon excitation imaging of pancreatic islets with various fluorescent probes. Diabetes 51, S25-S28, 2002.
Eto, K., Yamashita, T., Tsubamoto, Y., Terauchi, Y., Hirose, K., Kubota, N., Yamashita, S., Taka, J., Satoh, S., Sekihara, H., Tobe, K., Iino, M., Noda, M., Kimura, S., and Kadowaki, T. Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca²⁺] elevation signals. Diabetes 51, 87-97, 2002.

2001

Matsuzaki, M., Ellis-Davies, G.C.R., Nemoto, T., Miyashita, Y., Iino, M. and Kasai, H. Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nat. Neurosci. 4, 1086-1092, 2001.
Namiki, S., Hirose, K. and Iino, M. Mapping of heme-binding domains in soluble guanylyl cyclase b1 subunit. Biochem. Biophys. Res. Commun. 288, 798-804, 2001.
Okubo, Y., Kakizawa, S., Hirose, K., and Iino, M. Visualization of IP3 Dynamics Reveals a Novel AMPA Receptor-Triggered IP3 Production Pathway Mediated by Voltage-Dependent Ca²⁺Influx in Purkinje Cells. Neuron 32, 113-122, 2001 More Information
Fujiwara, A., Hirose, K., Yamazawa, T. and Iino, M. Reduced IP3 sensitivity of IP3 receptor in Purkinje neurons. NeuroReport 12, 2647-2651 2001.
Miyakawa, T., Mizushima, A., Hirose, K., Yamazawa, T., Bezprozvanny, I., Kurosaki, T. and Iino, M. Ca²⁺-sensor region of IP3 receptor controls intracellular Ca²⁺ signalling. EMBO J. 20, 1674-1680, 2001.
Takanari Inoue, Kazuya Kikuchi, Kenzo Hirose, Masamitsu Iino, Tetsuo Nagano. Small molecule-based laser inactivation of inositol 1,4,5-trisphosphate receptor. Chem. Biol. 8, 9-15, 2001.
Nemoto, T., Kimura, R., Ito, K., Tachikawa, A., Miyashita, Y., Iino, M. and Kasai, H. Sequential-replenishment mechanism of exocytosis in pancreatic acini. Nat. Cell Biol. 3, 253-258, 2001.
Akiko Hashimoto, Kenzo Hirose, Tomohiro Kurosaki and Masamitsu Iino. Negative Control of Store-Operated Ca²⁺ Influx by B Cell Receptor Cross-Linking. J. Immunol. 166, 1003-1008, 2001.

2000

Takeshima, H., Komazaki, S., Nishi, M., Iino, M. and Kangawa, K. Junctophilins: A novel family of junctional membrane complex proteins. Mol. Cell 6, 11-22, 2000
Nagai, Y., Miyazaki, M., Aoki, R., Zama, T., Inouye, S., Hirose, K., Iino, M. and Hagiwara, M. A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. Nat. Biotech. 18, 313-316, 2000

1999

Miyuki Nishi, Shinji Komazaki, Nagomi Kurebayashi, Yasuo Ogawa, Tetsuo Noda, Masamitsu Iino, and Hiroshi Takeshima. Abnormal Features in Skeletal Muscle from Mice Lacking Mitsugumin29. J. Cell Biol. 147, 1473-1480, 1999
Yukinori Asada, Toshiko Yamazawa, Kenzo Hirose, Tomonori Takasaka and Masamitsu Iino. Dynamic Ca²⁺ signalling in rat arterial smooth muscle cells under the control of local renin-angiotensin system. J. Physiol. 521, 497-505, 1999.
Kenzo Hirose, Shiro Kadowaki, Mao Tanabe, Hiroshi Takeshima and Masamitsu Iino Spatio-temporal dynamics of Inositol 1,4,5-trisphosphate that underlies complex Ca²⁺ mobilization patterns Science 284, 1527-1530, 1999.
Hashimoto, A., Hirose, K., Okada, H., Kurosaki, T. and Iino, M. Inhibitory modulation of B cell receptor-mediated Ca²⁺ mobilization by SH2 domain containing inositol 5'-phosphatase (SHIP). J. Biol. Chem. 274, 11203-11208, 1999.
Miyakawa, T., Maeda, A., Yamazawa, T., Hirose, K., Kurosaki, T. and Iino, M. Encoding of Ca²⁺signals by differential expression of IP3 receptor subtypes. EMBO J. 18, 1303-1308, 1999.
Hirabayashi, T., Kume, K., Hirose, K., Yokomizo, T., Iino, M., Itoh, H. and Shimizu, T. Critical duration of intracellular Ca²⁺ response required for continuous translocation and activation of cytosolic phospholipase A2. J. Biol. Chem. 274, 5163-5169, 1999.

1998

Okada, H., Bolland, S., Hashimoto, A., Kurosaki, M., Kabuyama, Y., Iino, M., Ravech, J.V., Kurosaki, T. Role of the inositol phosphatase SHIP in B cell receptor-induced Ca²⁺ oscillatory response. J. Immunol. 161, 5129-5132, 1998.
Takeshima, H., Komazaki, S., Hirose, K., Nishi, M., Noda, T. and Iino, M. Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2. EMBO J. 17, 3309-3316, 1998.
Hirose, K., Kadowaki, S. and Iino, M. (1998) Allosteric regulation by cytoplasmic Ca²⁺ and IP3of the gating of IP3 receptors in guinea pig vascular smooth muscle cells. J. Physiol. 506, 407-414.

1997

Kasai, Y., Yamazawa, T., Sakurai, T., Taketani, Y. and Iino, M. Endothelium-dependent frequency modulation of Ca²⁺ signaling in individual vascular smooth muscle cells of the rat. J. Physiol. 504, 349-357, 1997.
Ikemoto, T., Komazaki, S., Takeshima, H., Nishi, M., Noda, T., Iino, M. and Endo, M. Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors. J. Physiol. 501, 305-312, 1997.
Toshiko Yamazawa, Hiroshi Takeshima, Misa Shimuta and Masamitsu Iino A Region of the Ryanodine Receptor Critical for Excitation-Contraction Coupling in Skeletal Muscle. J. Biol. Chem., 272, 8161-8164, 1997.

1996

Yamazawa,T., Takeshima, H., Sakurai, T., Endo, M. and Iino, M. Subtype specificity of the ryanodine receptor for Ca²⁺ signal amplification in excitation-contraction coupling. EMBO J.15, 6172-6177, 1996.
Takeshima, H., Ikemoto, T., Nishi, M., Nishiyama, N, Shimuta, M., Sugitani, Y., Kuno, J., Saito, I., Saito, H., Endo, M., Iino, M. and Noda, M. Generation and characterization of mutant mice lacking ryanodine receptor type 3. J. Biol. Chem. 271, 19649-19652, 1996.

1995

Ikemoto, T., Iino, M. and Endo, M. (1995) Enhancing effect of calmodulin on Ca²⁺- induced Ca²⁺ release in the sarcoplasmic reticulum of rabbit skeletal muscle fibres. J. Physiol. 487, 573-582.
Takeshima, H., Yamazawa, T., Ikemoto, T., Takekura, H., Nishi, M., Noda, T. and Iino, M. (1995) Ca²⁺-induced Ca²⁺ release in myocytes from dyspedic mice lacking type-1 ryanodine receptor. EMBO J. 14, 2999-3006, 1995.
Kasai, Y., Tsutsumi, O., Taketani, Y., Endo, M. and Iino, M. (1995) Stretch-induced enhancement of contractions in uterine smooth muscle of rats. J. Physiol. 486, 373- 384.
Hirose, K. and Iino, M. (1995) Opening up Ca²⁺ stores with IP3. Nature 376, 301.

1994

Hirose, K. and Iino, M. (1994) Heterogeneity of channel density in inositol-1,4,5- trisphosphate- sensitive Ca²⁺ stores. Nature 372, 791-794.
Iino, M., Kasai, H. and Yamazawa, T. (1994) Visualization of neural control of intracellular Ca²⁺ concentration in single vascular smooth muscle cells in situ. EMBO J. 13, 5026-5031.
Takeshima, H., Iino, M., Takekura, H., Nishi, M., Kuno, J., Minowa, O., Takano, H. and Noda, T. (1994) Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene. Nature 369, 556- 559.
Oyamada, H., Murayama, T., Takagi, T., Iino, M., Iwabe, N., Miyata, T. Ogawa, Y. and Endo, M. (1994) Primary structure and distribution of ryanodine-binding protein isoforms of the bullfrog skeletal muscle. J. Biol. Chem. 269, 17206-17214.
Tsukioka, M., Iino, M. and Endo, M. (1994) pH dependence of inositol 1,4,5- trisphosphate-induced Ca²⁺ release in permeabilized smooth muscle cells of the guinea-pig. J. Physiol. 475, 369-375.

1993

Iino, M., Yamazawa, T., Miyashita, Y., Endo, M. and Kasai, H. (1993) Critical intracellular Ca²⁺concentration for all-or-none Ca²⁺ spiking in single smooth muscle cells. EMBO J. 12, 5287-5291.
Oyamada, H., Iino, M. and Endo, M. (1993) Effects of ryanodine on the properties of Ca²⁺release from the sarcoplasmic reticulum in skinned skeletal muscle fibres of the frog. J. Physiol. 470, 335-3348.

1992

Iino, M. and Endo, M. (1992) Calcium-dependent immediate feedback control of inositol 1,4,5-trisphosphate-induced Ca²⁺ release. Nature 360, 76-78.