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Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation.

Ueda K, Nakatsu Y, Yamamotoya T, Ono H, Inoue Y, Inoue M, Mizuno Y,
Matsunaga Y, Kushiyama A, Sakoda H, Fujishiro M, Takahashi S,
Matsubara A, Asano T

Oncotarget. 10, 1637-1648.


Retention of aberrant cortisol secretion in a patient with bilateral macronodular adrenal hyperplasia after unilateral adrenalectomy.

Tanaka S, Fujishiro M, Nakamura Y, Hatanaka Y, Abe M

Ther Clin Risk Manag. 15, 337-342.


The xanthine oxidase inhibitor febuxostat suppresses the progression of IgA nephropathy possibly via its anti-inflammatory and anti-fibrotic effects in the gddY mouse model.

Inoue MK, Yamamotoya T, Nakatsu Y, Ueda K, Inoue Y,
Matsunaga Y, Sakoda H, Fujishiro M, Ono H, Mori K, Sasaki K, Masaki T,
Suzuki Y, Asano T, Kushiyama A

Int J Mol Sci. 19, pii: E3967.


Development of Pin1 inhibitors and their potential as therapeutic agents.

Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK,
Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T

Curr Med Chem. in press.


Elsberg syndrome related to varicella zoster virus infection with painless skin lesions in an elderly woman with poorly controlled type 2 diabetes mellitus.

Saito H, Ebashi M, Kushimoto M, Ikeda J, Egashira F, Yamaguchi S,
Watanabe K, Ogawa K, Suzuki Y, Ishihara H, Fujishiro M

Ther Clin Risk Manag. 14, 1951-1954.


Roles of gut-derived secretory factors in the pathogenesis of non-alcoholic fatty liver disease and their possible clinical applications.

Okubo H, Kushiyama A, Nakatsu Y, Yamamotoya T, Matsunaga Y, Fujishiro M,
Sakoda H, Ohno H, Yoneda M, Asano T

Int J Mol Sci. 19, pii: E3064.


Protective effect of sex homone-binding globulin against metabolic syndrome: in vitro evidence showing anti-inflammatory and lipolytic effects on adipocytes and macrophages.

Yamazaki H, Kushiyama A, Sakoda H, Fujishiro M, Yamamotoya T,
Nakatsu Y, Kikuchi T, Kaneko S, Tanaka H, Asano T

Mediators Inflamm. 2018, 3062319.


Rationale and design of the STOP-OB study for evaluating the effects of tofogliflozin and glimepiride on fat deposition in type 2 diabetes patinets treated with metformin/DPP-4 inhibitor dual therapy.

Ishihara H, Anai M, Seino H, Kitazawa T, Ohashi H, Ai M, Inoue M,
Fujishiro M, Inazawa T, Kuroda H, Yamada M

Diabetes Ther. 9, 2117-2125.


Gut microbiota as a therapeutic target for metabolic disorders.

Okubo H, Nakatsu Y, Kushiyama A, Yamamotoya T, Matsunaga Y,
Inoue MK, Fujishiro M, Sakoda H, Ohno H, Yoneda M, Ono H, Asano T

Curr Med Chem. 25, 984-1001.


Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.

Yamamotoya T, Nakatsu Y, Kushiyama A, Matsunaga Y, Ueda K, Inoue Y, Inoue M, Sakoda H, Fujishiro M, Ono H, Kiyonari H, Ishihara H, Asano T

Sci Rep. 7, 13026.


Gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus.

Fujishiro M, Kushiyama A, Yamazaki H, Kaneko S, Koketsu Y, Yamamotoya T, Kikuchi T, Sakoda H, Suzuki R, Kadowaki T

World J Gastroenterol. 23, 6694-6704.


Severe hypertriglyceridemia possibly masked acute pancreatitis and led to a difficult diagnosis in an obese patient with ketoacidosis-onset type 2 diabetes.

Fujishiro M, Horita A, Nakagawara H, Mawatari T, Kishigami Y,
Tominaga Y, Moriyama M, Ishihara H

Intern Med. 56, 2611-2616.


The SGLT2 Inhibitor luseogliflozin rapidly normalizes aortic mRNA levels of inflammation-related but not lipid-metabolism-related genes and suppresses atherosclerosis in diabetic ApoE KO mice.

Nakatsu Y, Kokubo H, Bumdelger B, Yoshizumi M, Yamamotoya T, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Fujishiro M, Kushiyama A, Ono H, Sakoda H, Asano T.

Int J Mol Sci. 18, E1704.


The prolyl isomerase Pin1 increases β cell proliferation and enhances insulin secretion.

Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H,
Ishihara H, Asano T

J Biol Chem. 292, 11886-11895.


Reduced SHARPIN and LUBAC formation may contribute to CCl4- or acetaminophen-induced liver cirrhosis in mice.

Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H

Int J Mol Sci. 18, E326.


A case of insulin allergy successfully managed using multihexamer-forming insulin degludec combined with liraglutide.

Fujishiro M, Izumida Y, Takemiya S, Kuwano Y, Takamoto I, Suzuki R, Yamauchi T, Ueki K, Kadowaki T.

Diabet Med. 33, e26-e29.


Controversy regarding gastric cancer and diabetes.

Fujishiro M, Ishihara H

J Gastroenterol. 51, 80-81.


Octreotide for hypoglycemia caused by sulfonylurea and DPP-4 inhibitor.

Yamaguchi S, Ikejima M, Furukawa A, Abe M, Nakazaki M,
Ishihara H

Diabetes Res Clin Pract. 109, e8-e10.


Addition of sitagliptin or metformin to insulin monotherapy improves blood glucose control via different effects on insulin and glucagon secretion in hyperglycemic Japanese patients with type 2 diabetes.

Otsuka Y,Yamaguchi S, Furukawa A, Kosuda M, Nakazaki M,
Ishihara H

Endocr J. 62, 133-143.


Usefulness of the Pain Vision PS-2100, a device for the quantitative analysis of perception and pain sensation, for evaluating early stage dabetic polyneuropathy

Okamoto M, Egashira F, Taki M, Nakajima H, Ogihara N, Takamura H,
Yoshikawa S, Hayashi Y, Ishihara H

J Japan Diab Soc. 56, 343-349.