Li X, Guo L, Sato F, Kitayama T, Tewari N, Makishima M, Hamada N, Liu Y, Bhawal UK. Dec2 negatively regulates bone resorption in periodontitis. J Periodontal Res 57: 1056-1069, 2022
Takada I, Hidano S, Takahashi S, Yanaka K, Ogawa H, Tsuchiya M, Yokoyama A, Sato S, Ochi H, Nakagawa T, Kobayashi T, Nakagawa S, Makishima M. Transcriptional coregulator Ess2 controls survival of post-thymic CD4+ T cells through the Myc and IL-7 signaling pathways. J Biol Chem 298: 102342, 2022
Sasaki Y, Abe T, Kawamura N, Keitoku T, Shibata I, Ohno S, Ono K, Makishima M. Prediction of the need for emergency endoscopic treatment for upper gastrointestinal bleeding and new score model: A retrospective study. BMC Gastroenterol 22: 337, 2022
Liu W, Östberg NK, Yalcinkaya M, Dou H, Endo-Umeda K, Tang Y, Hou X, Xiao T, Filder T, Abramowicz S, Yang YG, Soehnlein O, Tall AR, Wang N. Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis. J Clin Invest 132: e155724, 2022
Katafuchi T, Makishima M. Molecular basis of bile acid-FXR-FGF15/19 signaling axis. Int J Mol Sci 23: 6046, 2022
Endo-Umeda K, Kim E, Thomas DG, Liu W, Dou H, Yalcinkaya M, Abramowicz S, Xiao T, Antonson P, Gustafsson JÅ, Makishima M, Reilly MP, Wang N, Tall AR. Myeloid LXR (liver X receptor) deficiency induces inflammatory gene expression in foamy macrophages and accelerates atherosclerosis. Arterioscler Thromb Vasc Biol 42: 719-731, 2022
Wang X, Tewari N, Sato F, Tanimoto K, Thangavelu L, Makishima M, Bhawal UK. Biphasic functions of sodium fluoride (NaF) in soft and in hard periodontal tissues. Int J Mol Sci 23: 962, 2022
Yoshihara A, Kawasaki H, Masuno H, Takada K, Numoto N, Ito N, Hirata N, Kanda Y, Ishizawa M, Makishima M, Kagechika H, Tanatani A. Lithocholic acid amides as potent vitamin D receptor agonists. Biomolecules 12: 130, 2022
Adachi K, Ishizawa M, Uno S, Kubota H, Henmi T, Koshinaga T, Makishima M, Sakurai K. Oral benzo[a]pyrene administration attenuates dextran sulfate sodium-induced colitis in mice. Chemi Biol Ineteract 353: 109802, 2022
Ando K, Ohira M, Takada I, Cázares-Ordoñez V, Suenaga Y, Nagase H, Kobayashi S, Koshinaga T, Kamijo T, Makishima M, Wada S. FGFR2 loss sensitizes MYCN-amplified neuroblastoma CHP134 cells to CHK1 inhibitor-induced apoptosis. Cancer Sci 113: 587-596, 2022
Ohni S, Yamaguchi H, Hirotani Y, Nakanishi Y, Midorikawa Y, Sugitani M, Naruse H, Nakayama T, Makishima M, Esumi M. Direct molecular evidence for both multicentric and monoclonal carcinogenesis followed by transdifferentiation from hepatocellular carcinoma to cholangiocarcinoma in a case of metachronous liver cancer. Oncol Lett 23: 22, 2022
Dou H, Kotini A, Liu W, Fidler T, Endo-Umeda K , Sun X, Olszewska M, Xiao T, Abramowicz S, Yalcinkaya M, Hardaway B, Tsimikas S, Que X, Bick A, Emdin C, Natarajan P, Papapetrou EP, Witztum JL, Wang N, Tall AR. Oxidized phospholipids promote NETosis and arterial thrombosis in LNK(SH2B3) deficiency. Circulation 144: 1940-1954, 2021
Endo-Umeda K, Nakashima H, Uno S, Toyoshima S, Umeda N, Komine-Aizawa S, Seki S, Makishima M. Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice. Sci Rep 11: 22595, 2021
Ishizawa Μ, Hirayu Α, Makishima Μ. Zinc inhibits cadherin 1 expression induced by 1α,25-dihydroxyvitamin D3 in colon cancer cells. Anticancer Res 41: 5453-5459, 2021
Wang X, Sato F, Tanimoto K, Makishima M, Bhawal UK. The potential roles of Dec1 and Dec2 in periodontal inflammation. Int J Mol Sci 22: 10349, 2021
Kobayashi H, Nakai T, Nakanishi Y, Esumi M, Masuda S. Phylogenetic analysis of combined lobular and ductal carcinoma of the breast. Mol Med Rep 24: 718, 2021
Ishikiriyama T, Nakashima H, Endo-Umeda K, Nakashima M, Ito S, Kinoshita M, Ikarashi M, Makishima M, Seki S. Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation. PLoS ONE 16: e0254886, 2021
Morimoto J, Miyamoto K, Ichikawa Y, Uchiyama M, Makishima M, Hashimoto Y, Ishikawa M. Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog. Sci Rep 11: 12697, 2021
Oka S, Li X, Zhang F, Tewari N, Wang C, Kim I, Zhong L, Hamada N, Oi Y, Makishima M, Liu Y, Bhawal UK. Inhibition of Dec1 provides biological insights into periodontal pyroptosis. All Life 14: 300-307, 2021
Oka S, Li X, Zhang F, Tewari N, Kim I, Chen C, Zhong L, Hamada N, Oi Y, Makishima M, Liu Y, Bhawal UK. Loss of Dec1 prevents autophagy in inflamed periodontal ligament fibroblast. Mol Biol Rep 48: 1423-1431, 2021
Oka S, Li X, Sato F, Zhang F, Tewari N, Kim I, Zhong L, Hamada N, Makishima M, Liu Y, Bhawal UK. A deficiency of Dec2 triggers periodontal inflammation and pyroptosis. J Periodontal Res 56: 492-500, 2021
Oka S, Li X, Zhang F, Tewari N, Ma R, Zhong L, Makishima M, Liu Y, Bhawal UK. MicroRNA-21 facilitates osteoblast activity. Biochem Biophys Rep 25: 100894, 2021
Yukawa-Takamatsu K, Wang Y, Watanabe M, Takamura Y, Fujihara M, Nakamura-Nakayama M, Yamada S, Kikuzawa S, Makishima M, Kawasaki M, Ito S, Nakano S, Kakuta H. Convenient retinoid X receptor binding assay based on fluorescence change of the antagonist NEt-C343. J Med Chem 64: 861-870, 2021
Watanabe M, Fujihara M, Motoyama T, Kawasaki M, Yamada S, Takamura Y, Ito S, Makishima M, Nakano S, Kakuta H. Discovery of a “gatekeeper” antagonist that blocks entry pathway to retinoid X receptors without allosteric ligand inhibition in permissive RXR heterodimers. J Med Chem 64: 430-439, 2021
Ichikawa Y, Hiramatsu M, Mita Y, Makishima M, Matsumoto Y, Masumoto Y, Muranaka A, Uchiyama M, Hashimoto Y, Ishikawa M. meta-Non-flat substituents: A novel molecular design to improving aqueous solubility in small molecule drug discovery. Org Biomol Chem 19: 446-456, 2021
Oka S, Li X, Zhang F, Tewari N, Zhong L, Makishima M, Liu Y, Bhawal UK. Dec2 attenuates autophagy in inflamed periodontal tissues. Immun Inflamm Dis 9: 265-273, 2021
Terui R, Yanase Y, Yokoo H, Suhara Y, Makishima M, Demizu Y, Misawa T. Development of novel selective TGR5 ligands based on 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphtaklene skeleton. ChemMedChem 16: 458-462, 2021
Saga R, Uchida T, Takino Y, Kondo Y, Kobayashi H, Kinoshita M, Saitoh D, Ishigami A, Makishima M. Radiation-induced gastrointestinal syndrome is exacerbated in vitamin C insufficient SMP30/GNL knockout mice. Nutrition 81: 110931, 2021
Hayashi K, Suzuki Y, Fujimoto C, Kanzaki S. Molecular mechanisms and biological functions of autophagy for genetics of hearing impairment. Genes 11: 1331, 2020
Li X, Le HT, Sato F, Kang TH, Makishima M, Zhong L, Liu Y, Guo L, Bhawal UK. Dec1 deficiency protects the heart from fibrosis, inflammation, and myocardial cell apoptosis in a mouse model of cardiac hypertrophy. Biochem Biophys Res Commun 532: 513-519, 2020
Ando K, Cázares-Ordoñez V, Makishima M, Yokoyama A, Suenaga Y, Nagase H, Kobayashi S, Kamijo T, Koshinaga T, Wada S. CEP131 abrogates CHK1 inhibitor-induced replication defects and is associated with unfavorable outcome in neuroblastoma. J Oncol 2020: 2752417, 2020
Nishida S, Ishizawa M, Kato S, Makishima M. Vitamin D receptor deletion changes bile acid composition in mice orally administered chenodeoxycholic acid. J Nutr Sci Vitaminol 66: 370-374, 2020
Takada I, Makishima M. Peroxisome proliferator-activated receptor agonists and antagonists: a patent review (2014-present). Expert OpinTher Pat 30: 1-13, 2020
Nishioka T, Endo-Umeda K, Ito Y, Shimoda A, Takeuchi A, Tode C, Hirota Y, Osakabe N, Makishima M, Suhara Y. Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives. Molecules 24: 4316, 2019
Endo-Umeda K, Makishima M. Liver X receptors regulate cholesterol metabolism and immunity in hepatic nonparenchymal cells. Int J Mol Sci 20: 5045, 2019
Yamada S, Kawasaki M, Fujihara M, Watanabe M, Takamura Y, Takioku M, Nishioka H, Takeuchi Y, Makishima M, Motoyama T, Ito S, Tokiwa H, Nakano S, Kakuta H. Competitive binding assay with an umbelliferone-based fluorescent rexinoid for retinoid X receptor ligand screening. J Med Chem 62: 8809-8818, 2019
Nakahashi M, Esumi M, Tokuhashi Y. Detection of apoptosis and matrical degeneration within the intervertebral discs of rats due to passive cigarette smoking. PLoS One 14: e0218298, 2019
Ando K, Nakamura Y, Nagase H, Nakagawara A, Koshinaga T, Wada S, Makishima M. Co-inhibition of the DNA damage response and CHK1 enhances apoptosis of neuroblastoma cells. Int J Mol Sci 20: 3700, 2019
Maekawa T, Kato S, Kawamura T, Takada K, Sone T, Ogata H, Saito K, Izumi T, Nagao S, Takano K, Okada Y, Tachi N, Teramoto M, Horiuchi T, Saga R, Endo-Umeda K, Uno S, Osawa Y, Kobayashi A, Kobayashi S, Sato K, Hashimoto M, Suzu S, Usuki K, Morishita S, Araki M, Makishima M, Komatsu N, Kimura F. Increased SLAMF7high monocytes in myelofibrosis patients harboring JAK2V617F provide a therapeutic target of elotuzumab. Blood 134; 814-825, 2019
Umeda N, Endo-Umeda K, Nakashima H, Kato S, Seki S, Makishima M. Concanavalin A-induced acute hepatitis is attenuated in vitamin D receptor knockout mice with decreased immune cell function. J Leukoc Biol 106: 791-801, 2019
Uno S, Sakai M, Fujinari Y, Hosono T, Seki T, Makishima M. Diallyl trisulfide enhances benzo[a]pyrene-induced CYP1A1 expression and metabolic activation in hepatic HepG2 cells. Anticancer Res 39: 2369-2375, 2019
Uno S, Shimizu T, Tanaka T, Ashiba H, Fujimaki M, Tanaka M, Awazu K, Makishima M. Application of a waveguide-mode sensor to blood testing for hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infection. Sensors 19: 1729, 2019
Nanjyo S, Ohgane K, Yoshioka H, Makishima M, Hashimoto Y, Noguchi-Yachide M. Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton. Bioorg Med Chem 27: 1952-1961, 2019
Fouache A, Zabaiou N, de Joussineau C, Morel L, Silvente-Poirot S, Namsi A, Lizard G, Poirot M, Makishima M, Baron S, Lobaccaro JA, Trousson A. Flavonoids differentially modulate Liver X Receptors activity. Structure-function relationship analysis. J Steroid Biochem Mol Biol 190: 173-182, 2019
Chuma M, Makishima M, Imai T, Tochikura N, Suzuki S, Kuwana T, Sawada N, Iwabuchi S, Sekimoto M, Nakayama T, Sakaue T, Kikuchi N, Yoshida Y, Kinoshita K. Relationship between hemoglobin levels and vancomycin clearance in patients with sepsis. Eur J Clin Pharmacol 75: 929-937, 2019
Onuki M, Watanabe M, Ishihara N, Suzuki K, Takizawa K, Hirota M, Yamada T, Egawa A, Shibahara O, Nishii M, Fujihara M, Makishima M, Takahashi D, Furusawa Y, Kakuta H, Hase K. A partial agonist for retinoid X receptor mitigates experimental colitis. Int Immunol 31:251-262, 2019
Nakai T, Sakurada A, Endo T, Kobayashi H, Masuda S, Makishima M, Esumi M. Caution for simple sequence repeat number variation in the mitochondrial DNA D‑loop to determine cancer‑specific variants. Oncol Lett 17: 1883-1888, 2019
Wada T, Ichihashi Y, Suzuki E, Kosuge Y, Ishige K, Uchiyama T, Makishima M, Nakao R, Oishi K, Shimba S. Deletion of Bmal1 prevents diet-induced ectopic fat accumulation by controlling oxidative capacity in the skeletal muscle. Int J Mol Sci 19: 2813, 2018
Nishiyama Y, Fujii S, Makishima M, Hashimoto Y, Ishikawa M. Efficient lead finding, activity enhancement and preliminary selectivity control of nuclear receptor ligands bearing a phenanthridinone skeleton. Int J Mol Sci 19: 2090, 2018
Otero R, Ishizawa M, Numoto N, Ikura T, Ito N, Tokiwa H, Mourino A, Makishima M, Yamada S. 25S-Adamantyl-23-yne-26,27-dinor-1α,25-dihydroxyvitamin D3: synthesis, tissue selective biological activities and X-ray crystal structural analysis of its vitamin D receptor complex. J Med Chem 61: 6658-6673, 2018
Ishizawa M, Akagi D, Makishima M. Lithocholic acid is a vitamin D receptor ligand that acts preferentially in the ileum. Int J Mol Sci 19: 1975, 2018
Kainuma M, Takada I, Makishima M, Sano K. Farnesoid X receptor activation enhances transforming growth factor β-induced epithelial-mesenchymal transition in hepatocellular carcinoma cells. Int J Mol Sci 19: 1898, 2018
Nishiyama Y, Mori S, Makishima M, Fujii S, Kagechika H, Hashimoto Y, Ishikawa M. Novel non-steroidal progesterone receptor (PR) antagonists with a phenanthridinone skeleton. ACS Med Chem Lett 9: 641-645, 2018
Endo-Umeda K, Nakashima H, Komine-Aizawa S, Umeda N, Seki S, Makishima M. Liver X receptors regulate hepatic F4/80+CD11b+ Kupffer cells/macrophages and innate immune responses in mice.Sci Rep 18: 9281, 2018
Shioi R, Toyota Y, Noguchi-Yachide T, Ishikawa M, Yamaguchi T, Makishima M, Hashimoto Y, Ohgane K. Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands. Heterocycles 97: 854-864, 2018
Nakagawa M, Uno S, Iriyama N, Matsunawa M, Makishima M, Takeuchi J, Tsuboi I, Hatta Y, Takei M. Combined treatment with benzo[a]pyrene and 1α,25-dihydroxyvitamin D3 induces expression of plasminogen activator inhibitor 1 in monocyte/macrophage-derived cells. Toxicol Appl Pharmacol 345: 48-56, 2018
Takada I, Tsuchiya M, Yanaka K, Hidano S, Takahashi S, Kobayashi T, Ogawa H, Nakagawa S, Makishima M. Ess2 bridges transcriptional regulators and spliceosomal complexes via distinct interacting domains. Biochem Biophys Res Commun 497: 597-604, 2018
Uno S, Tanaka T, Ashiba H, Fujimaki M, Tanaka M, Hatta Y, Takei M, Awazu K, Makishima M. Sensitive typing of reverse ABO blood groups with a waveguide-mode sensor. J Biosci Bioeng 126: 131-137, 2018
Endo-Umeda K, Nakashima H, Umeda N, Seki S, Makishima M. Dysregulation of Kupffer cells/ macrophages and natural killer T cells in steatohepatitis in LXRα knockout male mice. Endocrinology 159: 1419-1432, 2018
Uno S, Nebert DW, Makishima M. Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. Food Chem Toxicol 113: 73-82, 2018
Nomura S, Endo-Umeda K, Fujii S, Makishima M, Hashimoto Y, Ishikawa M. Structural development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists with improved aqueous solubility. Bioorg Med Chem Lett 28: 796-801, 2018
Ishibashi M, Yamaguchi H, Hirotani Y, Sakurada A, Endo T, Sugitani M, Takayama T,Makishima M, Esumi M. Contradictory intrahepatic immune responses activated in high-load hepatitis C virus livers compared with low-load livers. Arch Virol 163: 855-865, 2018
Chuma M, Makishima M, Imai T, Tochikura N, Suzuki S, Kuwana T, Sawada N, Komatsu T, Sakaue T, Kikuchi N, Yoshida Y, Kinoshita K. Relationship between initial vancomycin trough levels and early-onset vancomycin-associated nephrotoxicity in critically ill patients. Ther Drug Monit 40: 109-114, 2018
Neelankal John A, Iqbal Z, Colley S, Morahan G, Makishima M, Jiang FX. Vitamin D receptor-targeted treatment to prevent pathological dedifferentiation of pancreatic β cells under hyperglycaemic stress. Diabetes Metab 44: 269-280, 2018
Nishina A, Itagaki M, Sato D, Kimura H, Hirai Y, Phay N, Makishima M. Rosiglitazone-like effect of vitexilactone, a constituent fromVitex trifoliaL. in 3T3-L1 preadipocytes.Molecules 22: 2030, 2017
Sakane R, Kimura K, Hirota Y, Ishizawa M, Takagi Y, Wada A, Kuwahara S, Makishima M, Suhara Y. Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities. Bioorg Med Chem Lett 27: 4881-4884, 2017
Endo-Umeda K, Aoyama A, Shimizu M, Ishikawa M, Hashimoto Y, Yamada S, Makishima M. 1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators. J Steroid Biochem Mol Biol 172: 136-148, 2017
Arichi N, Fujiwara S, Ishizawa M, Makishima M, Hua HD, Yamada K, Yamaoka Y, Takasu K. Synthesis and biological evaluation of steroidal derivatives bearing a small ring as vitamin D receptor agonists. Bioorg Med Chem Lett 27: 3408-3411-2017
Ishizawa M, Akagi D, Yamamoto J, Makishima M. 1α,25-Dihydroxyvitamin D3 enhances TRPV6 transcription through p38 MAPK activation and GADD45 expression. J Steroid Biochem Mol Biol 172: 55-61, 2017
Tamura M, Ishizawa M, Isojima T, Ozen S, Oka A, Makishima M, Kitanaka S. Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia. Sci Rep 7: 5102, 2017
Shioi R, Okazaki S, Noguchi-Yachide T, Ishikawa M, Makishima M, Hashimoto Y, Yamaguchi T. Switching subtype-selectivity: fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists. Bioorg Med Chem Lett 27: 3131-3134, 2017
Toyota Y, Nomura S, Makishima M, Hashimoto Y, Ishikawa M. Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression. Bioorg Med Chem Lett 27: 2776-2780, 2017
Shimizu T, Tanaka T, Uno S, Ashiba H, Fujimaki M, Tanaka M, Awazu K, Makishima M. Detection of antibodies against hepatitis B virus surface antigen and hepatitis C virus core antigen in plasma with a waveguide-mode sensor. J Biosci Bioeng 123: 760-764, 2017
Kuroda C, Ohki Y, Ashiba H, Fujimaki M, Awazu K, Makishima M. Design of a sedimentation hole in a microfluidic channel to remove blood cells from diluted whole blood. Jpn J Appl Phys 56: 037201, 2017
Misawa T, Fujisato T, Kanda Y, Ohoka N, Shoda T, Yorioka M, Makishima M, Sekino Y, Naito M, Demizu Y, Kurihara M. Design and synthesis of novel selective estrogen receptor degradation inducers based on diphenylheptane skeleton. MedChemComm 8: 239-246, 2017
Takada I, Makishima M. Control of inflammatory bowel disease and colorectal cancer by synthetic vitamin D receptor ligands. Curr Med Chem 24: 868-875, 2017
Chuma M, Makishima M, Imai T, Tochikura N, Sakaue T, Kikuchi N, Kinoshita K, Kaburaki M, Yoshida Y. Duration of systemic inflammatory response syndrome influences serum vancomycin concentration in patients with sepsis. Clin Ther 38: 2598-2609, 2016
Uchida H, Hasegawa Y, Takahashi H, Makishima M. 1α-Dihydroxyvitamin D3 and retinoic acid increase nuclear vitamin D receptor expression in monocytic THP-1 cells. Anticancer Res 36: 6297-6302, 2016
Okazaki S, Shioi R, Noguchi-Yachide T, Ishikawa M, Makishima M, Hashimoto Y, Yamaguchi T. Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists. Bioorg Med Chem 24: 5455-5461, 2016
Nomura S, Endo-Umeda K, Makishima M, Hashimoto Y, Ishikawa M. Development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists. ChemMedChem 11: 2347-2360, 2016
Okazaki S, Noguchi-Yachide T, Sakai T, Ishikawa M, Makishima M, Hashimoto Y, Yamaguchi T. Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity. Bioorg Med Chem 24: 5258-5269, 2016
Hiramatsu M, Ichikawa Y, Tomoshige S, Makishima M, Muranaka A, Uchiyama M, Yamaguchi T, Hashimoto Y, Ishikawa M. Improvement in aqueous solubility of retinoic acid receptor (RAR) agonists by bending the molecular structure. Chem Asian J 11: 2210-2217, 2016
Kurita D, Miyoshi H, Yoshida N, Sasaki Y, Kato S, Niino D, Sugita Y, Hatta Y, Takei M, Makishima M, Ohshima K. A clinicopathologic study of Lennert lymphoma and possible prognostic factors: The importance of follicular helper T-cell markers and the association with angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 40: 1249-1260, 2016
Imai T, Kosuge Y, Saito H, Uchiyama T, Wada T, Shimba S, Ishige K, Miyairi S, Makishima M, Ito Y. Neuroprotective effect of S-allyl-L-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition. J Pharmacol Sci 130: 185-188, 2016
Ashiba H, Fujimaki M, Awazu K, Tanaka T, Makishima M. Microfluidic chips for forward blood typing performed with a multichannel waveguide-mode sensor. Sensing and Bio-Sensing Research 7: 121-126, 2016
Fujita Y, Makishima M, Bhawal UK. Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. Biochem Biophys Res Commun 469: 477-482, 2016
Ashiba H, Hiroki M, Awazu K, Fu M, Ohki Y, Tanaka T, Makishima M. Rapid detection of hemagglutination using restrictive microfluidic channels equipped with waveguide-mode sensors. Jpn J Appl Phys 55: 027002, 2016
Takada I, Yogiashi Y, Makishima M. The ribosomal S6 kinase inhibitor BI-D1870 ameliorated experimental autoimmune encephalomyelitis in mice. Immunobiology 221: 188-192, 2016
Watarai Y, Ishizawa M, Ikura T, Zacconi F, Uno S, Ito N, Mouriño A, Tokiwa H,Makishima M, Yamada S. Synthesis, biological activities and X-ray crystal structural analysis of 25-hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D compounds. J Med Chem 58: 9510–9521, 2015
Misawa T, Yorioka M, Demizu Y, Noguchi-Yachide T, Ohoka N, Kurashima-Kinoshita M, Motoyoshi H, Nojiri H, Kittaka A, Makishima M, Naito M, Kurihara M. Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton. Bioorg Med Chem Lett 25: 5362-5366, 2015
Nomura S, Endo-Umeda K, Aoyama A, Makishima M, Hashimoto Y, Ishikawa M. Styrylphenylphthalimides as novel transrepression-selective liver X receptor (LXR) modulators. ACS Med Chem Lett 6: 902-907, 2015
Isojima T, Ishizawa M, Yoshimura K, Tamura M, Hirose S, Makishima M, Kitanaka S. Hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) caused by a VDRmutation; a novel mechanism of dominant inheritance. Bone Reports 2: 68-73, 2015
Shiraishi M, Yamamoto Y, Hirooka N, Obuchi Y, Tachibana S, Makishima M, Tanaka Y. A high concentration of triiodothyronine attenuates the stimulatory effect on hemin-induced erythroid differentiation of human erythroleukemia K562 cells. Endocr J 62: 431-330, 2015
Nunomura S, Okayama Y, Matsumoto K, Hashimoto N, Endo-Umeda K, Terui T,Makishima M, Ra C. Activation of LXRs using the synthetic agonist GW3965 represses the production of pro-inflammatory cytokines by murine mast cells. Allergol Int 64 (Suppl): S11-S17, 2015
Ashiba H, Fujimaki M, Awazu K, Fu M, Ohki Y, Tanaka T, Makishima M. Hemagglutination detection for blood typing based on waveguide-mode sensors. Sensing and Bio-Sensing Research 3: 59-64, 2015
Kawata K, Morishita K, Yamada S, Nakayama M, Kobayashi T, Furusawa Y. Arimoto-Kobayashi S, Oohashi T, Makishima M, Naitou H, Ishitsubo E, Tokiwa H, Tai A, Kakuta H. RXR partial agonist produced by side-chain repositioning of alkoxy RXR full agonist retains anti-type 2 diabetes activity without the adverse effects. J Med Chem 58: 912-926, 2015
Ohashi M, Gamo K, Tanaka Y, Waki M, Beniyama Y, Matsuno K, Wada J, Tenta M, Eguchi J, Makishima M, Matsuura N, Oyama T, Miyachi H. Structural design and synthesis of arylalkynyl amide-type peroxisome proliferator-activated receptor γ (PPARγ)-selective antagonists based on the helix12-folding inhibition hypothesis. Eur J Med Chem 90: 53-67, 2015
Takada I, Makishima M. Peroxisome proliferator-activated receptor γ ligands and their therapeutic applications: a patent review (2008-2014). Expert Opin Ther Pat 25: 175-191, 2015
Cázares-Ordoñez V, González-Duarte RJ, Díaz L, Ishizawa M, Uno S, Ortíz V, Ordoñez-Sánchez ML, Makishima M, Larrea F, Avila E. A cis-acting element in the promoter of human ether à go-go 1 potassium channel gene mediates repression by calcitriol in human cervical cancer cells. Biochem Cell Biol 93: 94-101, 2015
Takahashi H, Hatta Y, Iriyama N, Hasegawa Y, Uchida H, Nakagawa M, Makishima M, Takeuchi J, Takei M. Induced differentiation of human myeloid leukemia cells into M2 macrophages by combined treatment with retinoic acid and 1α,25-dihydroxyvitamin D3. PLoS ONE 9: e113722, 2014
Tanabe H, Yasui T, Kotani H, Nagatsu A, Makishima M, Amagaya S, Inoue M. Retinoic acid receptor agonist activity of naturally occurring diterpenes. Bioorg Med Chem, 22: 3204-3212, 2014
Kudo T, Ishizawa M, Maekawa K, Nakabayashi M, Watarai Y, Uchida H, Tokiwa H, Ikura T, Ito N, Makishima M, Yamada S. Combination of triple bond and adamantane ring on the vitamin D side chain produced partial agonists for vitamin D receptor. J Med Chem 57: 4073-4087, 2014
Nishiyama Y, Nakamura M, Misawa T, Nakagomi M, Makishima M, Ishikawa M, Hashimoto Y. Structure–activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand. Bioorg Med Chem 22: 2799-2808, 2014
Kajita D, Nakamura M, Matsumoto Y, Makishima M, Hashimoto Y. Design and synthesis of silicon-containing steroid sulfatase inhibitors possessing pro-estrogen antagonistic character. Bioorg Med Chem 22: 2244-2252, 2014
Lancaster ST, Blackburn J, Blom A, Makishima M, Ishizawa M, Mansell JP. 24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation. Steroids 83: 52-61, 2014
Uno S, Sakurai K, Nebert DW, Makishima M. Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta. Toxicology 316: 34-42, 2014
Imai T, Kosuge Y, Endo-Umeda K, Miyagishi H, Ishige K, Makishima M, Ito Y. Protective effect of S-allyl-L-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain. Amino Acids 46: 385-393, 2014
Endo-Umeda K, Yasuda K, Sugita K, Honda A, Ohta M, Ishikawa M, Hashimoto Y, Sakaki T, Makishima M. 7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity. J Steroid Biochem Mol Biol 140: 7-16, 2014
Nakabayashi M, Tsukahara Y, Iwasaki-Miyamoto Y, Mihori-Shimazaki M, Yamada S, Inaba S, Oda M, Shimizu M, Makishima M, Tokiwa H, Ikura T, Ito N. Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands. J Med Chem 56: 6745-6760, 2013
Nebert DW, Shi Z, Gálvez-Peralta M, Uno S, Dragin N. Oral Benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences—Cyp1 Knockout mouse lines as a paradigm. Mol Pharmaocl 84: 304-313, 2013
Ozeki J, Choi M, Endo-Umeda K, Sakurai K, Amano S, Makishima M. Enhanced transcription of pancreatic peptide YY by 1α-hydroxyvitamin D3 administration in streptozotocin-induced diabetic mice. Neuropeptides 47: 329-332, 2013
Maruyama K, Nakamura M, Tomoshige S, Sugita K, Makishima M, Hashimoto Y, Ishikawa M. Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): Discovery of an ERα-selective antagonist. Bioorg Med Chem Lett 23: 4031-4036, 2013
Tanaka T, Kuroda K, Ikeda M, Kato N, Shimizu K, Makishima M. Direct targeting of proteins to lipid droplets demonstrated by time-lapse live cell imaging. J Biosci Bioeng 116: 620-623, 2013
Sato A, Dodo K, Makishima M, Hashimoto Y, Sodeoka M. Synthesis and evaluation of 2,3-dinorprostaglandins: dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists. Bioorg Med Chem Lett 23: 3013-3017, 2013
Nakamura M, Makishima M, Hashimoto Y. Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: Selectivity switching by C/Si exchange. Bioorg Med Chem 21: 1643-1651, 2013
Sawai-Kuroda R, Kikuchi S, Shimizu YK, Sasaki Y, Kuroda K, Tanaka T, Yamamoto T, Sakurai K, Shimizu K. A polyphenol-rich extract from Chaenomeles sinensis (Chinese quince) inhibits influenza A virus infection by preventing primary transcription in vitro. J Ethnopharmacol 146: 866-872, 2013
Ohsawa F, Yamada S, Yakushiji N, Shinozaki R, Nakayama M, Kawata K, Hagaya M, Kobayashi T, Kohara K, Furusawa Y, Fujiwara C, Ohta Y, Makishima M, Naitou H, Tai A, Yoshikawa Y, Yasui H, Kakuta H. Mechanism of RXR partial agonistic action of CBt-PMN and structural development to increase potency. J Med Chem 56: 1865-1877, 2013
Tanaka T, Kuroda K, Ikeda M, Wakita T, Kato N, Makishima M. Hepatitis C virus NS4B targets lipid droplets through hydrophobic residues in the amphipathic helices. J Lipid Res 54: 881-892, 2013
Ishizawa M, Ogura M, Kato S, Makishima M. Impairment of bilirubin clearance and intestinal interleukin-6 expression in bile duct-ligated vitamin D receptor null mice. PLoS ONE 7: e51664, 2012
Nishikawa T, Shimizu K, Tanaka T, Kuroda K, Takayama T, Yamamoto T, Hanada N, Hamada Y. Bacterial neuraminidase rescues Influenza virus replication from inhibition by a neuraminidase inhibitor. PLoS ONE 7: e45371, 2012
Ohashi M, Nakagome I, Kasuga J, Nobusada H, Matsuno K, Makishima M, Hirono S, Hashimoto Y, Miyachi H. Design, synthesis and in vitro evaluation of a series of alpha-substituted phenylpropanoic acid PPAR gamma agonists to further investigate the stereochemistry-activity relationship. Bioorg Med Chem 20: 6375-6383, 2012
Choi M, Ozeki J, Hashizume M, Kato S, Ishihara H, Makishima M. Vitamin D receptor activation induces peptide YY transcription in pancreatic islets. Endocrinology 153: 5188-5199, 2012
Aoyama A, Endo-Umeda K, Kishida K, Ohgane K, Noguchi-Yachide T, Aoyama H, Ishikawa M, Miyachi H, Makishima M, Hashimoto Y. Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton. J Med Chem 55: 7360-7377, 2012
Matsunawa M, Akagi D, Uno S, Endo-Umeda K, Yamada S, Ikeda K, Makishima M. Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages. Drug Metab Dispos 40: 2059-2066, 2012
Misawa T, Hayashi H, Makishima M, Sugiyama Y, Hashimoto Y. E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: Structural development study and separation from farnesoid X receptor-agonistic activity. Bioorg Med Chem Lett 22: 3962-3966, 2012
Kakuta H, Yakushiji N, Shinozaki R, Ohsawa F, Yamada S, Ohta Y, Kawata K, Nakayama M, Hagaya M, Fujiwara C, Makishima M, Uno S, Tai A, Maehara A, Nakayama M, Oohashi T, Yasui H, Yoshikawa Y. RXR partial agonist CBt-PMN exerts therapeutic effects on type 2 diabetes without the side effects of RXR full agonists. ACS Med Chem Lett 3: 427–432, 2012
Endo-Umeda K, Uno S, Fujimori K, Naito Y, Saito K, Yamagishi K, Jeong Y, Miyachi H, Tokiwa H, Yamada S, Makishima M. Differential expression and function of alternative splicing variants of human liver X receptor alpha. Mol Pharmacol 81: 800-810, 2012
Ishizawa M, Kagechika H, Makishima M. NR4A nuclear receptors mediate carnitine palmitoyltransferase 1A gene expression by the rexinoid HX600. Biochem Biophys Res Commun 418: 780-785, 2012
Chuma M, Endo-Umeda K, Shimba S, Yamada S, Makishima M. Hairless modulates ligand-dependent activation of the vitamin D receptor-retinoid X receptor heterodimer. Biol Pharm Bull 35: 582-587, 2012
Kakuta H, Ohsawa F, Yamada S, Makishima M, Tai A, Yasui H, Yoshikawa Y. Feasibility of structural modification of RXR agonists to separate blood glucose-lowering action from adverse effects: studies in KKAy type 2 diabetes model mice. Biol Pharm Bull 35: 629-633, 2012
Hirano T, Hirose K, Sakurai K, Makishima M, Sasaki K, Amano S. Inhibition of tumor growth by antibody to ADAMTS1 in mouse xenografts of breast cancer. Anticancer Res 31: 3839-3842, 2011
Nakayama M, Yamada S, Ohsawa F, Ohta Y, Kawata K, Makishima M, Kakuta H. Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IB. ACS Med Chem Lett 2: 896-900, 2011
Choi M, Yamada S, Makishima M. Dynamic and ligand-selective interactions of vitamin D receptor with retinoid X receptor and cofactors in living cells. Mol Pharmacol 80: 1147-1155, 2011
Goto T, Kim YI, Funakoshi K, Teraminami A, Uemura T, Hirai S, Lee JY, Makishima M, Nakata R, Inoue H, Senju H, Matsunaga M, Horio F, Takahashi N, Kawada T. Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARalpha-dependent and -independent pathways. Am J Physiol Endocrinol Metab 301: E1022-E1032, 2011
Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA. FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1alpha pathway. Cell Metab 8: 729-738, 2011
He J, Nishida S, Xu M, Makishima M, Xie W. PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts. Gastroenterology 140: 2095-2106, 2011
Uemura T, Goto T, Kang MS, Mizoguchi N, Hirai S, Lee JY, Nakano Y, Shono J, Hoshino S, Taketani K, Tsuge N, Narukami T, Makishima M, Takahashi N, Kawada T. Diosgenin, the main aglycon of Fenugreek, inhibits LXRalpha activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice. J Nutr 141: 17-23, 2011
Ozeki J, Uno S, Ogura M, Choi M, Maeda T, Sakurai K, Matsuo S, Amano S, Nebert DW,Makishima M. Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice. Toxicology 280: 10-17, 2011
Schmidt DR, Schmidt S, Holmstrom SR, Makishima M, Yu RT, Cummins CL, Mangelsdorf DJ, Kliewer SA. Akr1B7 is induced by the farnesoid X receptor and metabolizes bile acids. J Biol Chem 286: 2425-2432, 2011
Ohsawa F, Morishita K, Yamada S, Makishima M, Kakuta H. Modification at the lipophilic domain of RXR agonists differentially influences activation of RXR heterodimers. ACS Med Chem Lett 1: 521-525, 2010
Nunomura S, Makishima M, Ra C. Liver X receptors and immune regulation. BioMol Concepts 1: 381-387, 2010
Shi Z, Dragin N, Miller ML, Stringer KF, Johansson E, Chen J, Uno S, Gonzalez FJ, Rubio CA, Nebert DW. Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype. Int J Cancer 127: 2334-2350, 2010
Fukunaga M. Nunomura S, Nishida S, Endo K, Gon Y, Hashimoto S, Hashimoto Y, Okayama Y, Makishima M, Ra C. Mast cell death induced by 24(S),25-epoxycholesterol. Exp Cell Res 316: 3272-3281, 2010
Kasuga J, Ishikawa M, Yonehara M, Makishima M, Hashimoto Y, Miyachi H. Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta-selective partial agonists by disruption of molecular planarity/symmetry. Bioorg Med Chem 18: 7164-7173, 2010
Kotani H, Tanabe H, Mizukami H, Makishima M, Inoue M. Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. J Nat Prod 73: 1332-1336, 2010
Yamada S, Ohsawa F, Fujii S, Shinozaki R, Makishima M, Naitou H, Enomoto S, Tai A, Kakuta H. Fluorescent retinoid X receptor ligands for fluorescence polarization assay. Bioorg Med Chem Lett 20: 5143-5146, 2010
Fujii S, Ohsawa F, Yamada S, Shinozaki R, Fukai R, Makishima M, Enomoto S, Tai A, Kakuta H. Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation. Bioorg Med Chem Lett 20: 5139-5142, 2010
Tanaka T, Hasegawa Y, Saito M, Ikeda M, Kato N. Generation of single-chain Fvs against detergent-solubilized recombinant antigens with a simple coating procedure. J Biosci Bioeng 110: 374-376, 2010
Yamagishi K, Tokiwa H, Makishima M, Yamada S. Interactions between 1α,25(OH)2D3 and residues in the ligand-binding pocket of the vitamin D receptor: a correlated fragment molecular orbital study. J Steroid Biochem Mol Biol 121: 63-67, 2010
Mita Y, Dodo K, Noguchi-Yachide T, Miyachi H, Makishima M, Hashimoto Y, Ishikawa M. LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators. Bioorg Med Chem Lett 20: 1712-1717, 2010
Nunomura S, Endo K, Makishima M, Ra C. Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners. FEBS Lett 584: 1143-1148, 2010
Kasuga J, Ishida S, Yamasaki D, Makishima M, Doi T, Hashimoto Y, Miyachi H. Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta selective antagonists. Bioorg Med Chem Lett 19: 6595-6599, 2009
Cho Y, Noshiro M, Choi M, Morita K, Kawamoto T, Fujimoto K, Kato Y, Makishima M. The basic helix-loop-helix proteins DEC1 and DEC2 function as corepressors of retinoid X receptors. Mol Pharmacol 76: 1360-1369, 2009
Nishida S, Ozeki J, Makishima M. Modulation of bile acid metabolism by 1alpha-hydroxyvitamin D3 administration in mice. Drug Metab Disp 37: 2037-2044, 2009
Aoyama A, Aoyama H, Makishima M, Hashimoto Y, Miyachi H. Liver X receptor (LXR) modulators with dibenz[b,f][1,4]oxazepin-11-one, (Z)-dibenz[b,f]azocin-6-one, and 11,12-dihydrodibenz[b,f]azocin-6-one skeletons. Heterocycles 78: 2209-2216, 2009
Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, Nebert DW. CYP1A1 and CYP1A2 expression: comparing ‘humanized’ mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines. Toxicol Appl Pharmacol 237: 119-126, 2009
Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M. The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages. Toxicol Sci 109: 50-58, 2009
Amano Y,Cho Y, Matsunawa M, Komiyama K, Makishima M. Increased nuclear expression and transactivation of vitamin D receptor by the cardiotonic steroid bufalin in human myeloid leukemia cells. J Steroid Biochem Mol Biol 114: 144-151, 2009
Miyauchi Y, Sakaguchi N, Okada T, Makishima M, Ozono K, Michigami T. Oncogenic nucleoporin CAN/Nup214 interacts with vitamin D receptor and modulates its function. J Cell Biochem 106: 1090-1101, 2009
Yokoyama A, Makishima M, Choi M, Cho Y, Nishida S, Hashimoto Y, Terui T. Induction of SREBP-1c mRNA by differentiation and LXR ligand in human keratinocytes. J Invest Dermatol 129: 1395-1401, 2009
Dong H, Dalton TP, Miller ML, Chen Y, Uno S, Shi Z, Shertzer HG, Bansal S, Avadhani NG, Nebert DW. Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle. Mol Pharmacol 75: 555-567, 2009
Morishita K, Yakushiji N, Ohsawa F, Takamatsu K, Matsuura N, Makishima M, Kawahata M, Yamaguchi K, Tai A, Sasaki K, Kakuta H. Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity. Bioorg Med Chem Lett 19: 1001-1003, 2009
Ogura M, Nishida S, Ishizawa M, Sakurai K, Shimizu M, Matsuo S, Amano S, Uno S, Makishima M. Vitamin D3 modulates the expression of bile acid regulatory genes and represses inflammation in bile duct-ligated mice. J Pharmacol Exp Ther 328: 564-570, 2009
Noshiro M, Usui E, Kawamoto T, Sato F, Nakashima A, Ueshima T, Honda K, Fujimoto K, Honma S, Honma K, Makishima M, Kato Y. The liver X receptors (LXRalpha and LXRbeta) are potent regulators for hepatic Dec1 expression. Genes Cells 14: 29-40, 2009
Uno S, Endo K, Jeong Y, Kawana K, Miyachi H, Hashimoto Y, Makishima M. Suppression of β-catenin signaling by liver X receptor ligands. Biochem Pharmacol 77: 186-195, 2009
Suzuki T, Igari S, Hirasawa A, Hata M, Ishiguro M, Fujieda H, Itoh Y, Hirano T, Nakagawa H, Ogura M, Makishima M, Tsujimoto G, Miyata N. Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists. J Med Chem 51: 7640-7644, 2008
Yoshimaru T, Suzuki Y, Inoue T, Nishida S, Ra C. Extracellular superoxide released from mitochomdria mediates mast cell death by advanced glycation end products. Biochim Biophys Acta 1783: 2332-2343, 2008
Kasuga J, Oyama T, Nakagome I, Makishima M, Hirono S, Morikawa K, Hashimoto Y, Miyachi H. Determination of the critical amino acids involved in the peroxisome proliferator-activated receptor (PPAR) delta selectivity of phenylpropanoic acid-derived agonists. ChemMedChem 3: 1662-1666, 2008
Hozoji M, Munehira Y, Ikeda Y, Makishima M, Matsuo M, Kioka N, Ueda K. Direct interaction of nuclear receptor LXRbeta with ABCA1 modulates cholesterol efflux. J Biol Chem 283: 30057-30063, 2008
Aoyama A, Aoyama H, Dodo K, Makishima M, Hashimoto Y, Miyachi M. LXR antagonists with a 5-substituted phenanthridin-6-one skeleton: synthesis and LXR transrepression activities of conformationally restricted carba-T0901317 analogs. Heterocycles 76: 137-142, 2008
Nakabayashi M, Yamada S, Yoshimoto N, Tanaka T, Igarashi M, Ikura T, Ito N, Makishima M, Tokiwa H, DeLuca HF, Shimizu M. Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: structural basis for vitamin D receptor antagonism and partial agonism. J Med Chem 51: 5320-5329, 2008
Kasuga J, Oyama T, Hirakawa Y, Makishima M, Morikawa K, Hashimoto Y, Miyachi H. Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists; effect of introduction of fluorine at the linker part. Bioorg Med Chem Lett 18: 4525-4528, 2008
Araya Y, Kasuga J, Toyota K, Hirakawa Y, Oyama T, Makishima M, Morikawa K, Hashimoto Y, Miyachi H. Structure-based design and synthesis of fluorescent PPARalpha/delta co-agonist and its application as a probe for fluorescent polarization assay of PPARdelta ligands. Chem Pharm Bull 56: 1357-1359, 2008
Nakagawa A, Uno S, Makishima M, Miyachi H, Hashimoto Y. Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton. Bioorg Med Chem 16: 7046-7054, 2008
Ohgane K, Kasuga J, Ohyama T, Hirakawa Y, Morikawa K, Makishima M, Hashimoto Y, Miyachi H. Peroxisome proliferator-activated receptor (PPAR) agonists with 3,4-dihydro-2H-benzo[e][1,3]oxazine and 2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine skeletons: effects of cyclization of linker moiety on PPAR-agonistic activity. Heterocycles 75: 2187-2192, 2008
Dodo K, Aoyama A, Noguchi-Yachide T, Makishima M, Miyachi H, Hashimoto Y. Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem 16: 4272–4285, 2008
Takamatsu K, Takano A, Yakushiji N, Morohashi K, Morishita KI, Matsuura N, Makishima M, Tai A, Sasaki K, Kakuta H. The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRalpha/beta-dual agonist). ChemMedChem 3: 780-787, 2008
Endo K, Uno S, Seki T, Ariga T, Kusumi Y, Mitsumata M, Yamada S, Makishima M. Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene. Toxicol Appl Pharmacol 230: 135-143, 2008
Horie A, Akimoto M, Tsumura H, Makishima M, Taketani T, Yamaguchi S, Honma Y. Induction of differentiation of myeloid leukemia cells in primary culture in response to lithocholic acid acetate, a bile acid derivative, and cooperative effects with another differentiation inducer, cotylenin A. Leuk Res 32: 1112-1123, 2008
Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M. Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia. J Lipid Res 49: 763-772, 2008
Uno S, Dragin N, Miller ML, Dalton TP, Gonzalez FJ, Nebert DW. Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. Free Radic Biol Med 44: 570-583, 2008
Kasuga J, Yamasaki D, Ogura K, Shimizu M, Sato M, Makishima M, Doi T, Hashimoto Y, Miyachi H. SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail. Bioorg Med Chem Lett 18: 1110-1115, 2008
Takamatsu K, Takano A, Yakushiji N, Morishita K, Matsuura N, Makishima M, Ali HI, Akaho E, Tai A, Sasaki K, Kakuta H. Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype-preference: RXRα-preferential agonist possessing a sulfonamide moiety. ChemMedChem 3: 454-460, 2008
Yoshimoto N, Inaba Y, Yamada S, Makishima M, Shimizu M, Yamamoto K. 2-Methylene 19-nor-25-dehydro-1α-hydroxyvitamin D3 26,23-lactones: synthesis, biological activities and molecular basis of passive antagonism. Bioorg Med Chem 16: 457-473, 2008
Noguchi-Yachide T, Miyachi H, Aoyama H, Aoyama A, Makishima M, Hashimoto Y. Structural development of liver X receptor (LXR) antagonists derived from thalidomide-related glucosidase inhibitors. Chem Pharm Bull 55: 1750-1754, 2007
Noshiro M, Usui E, Kawamoto T, Kubo H, Fujimoto K, Furukawa M, Honma S, Makishima M, Honma K, Kato, Y. Multiple regulatory mechanisms for the circadian expression of hepatic Cyp7a. J Biol Rhythms 22: 299-311, 2007
Kasuga J, Nakagome I, Aoyama A, Sako K, Ishizawa M, Ogura M, Makishima M, Hirono S, Hashimoto Y, Miyachi H. Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists. Bioorg Med Chem 15: 5177-5190, 2007
Fujieda H, Usui S, Suzuki T, Nakagawa H, Ogura M, Makishima M, Miyata N. Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARδ-selective agonists. Bioorg Med Chem Lett 17: 4351-4357, 2007
Usui S, Fujieda H, Suzuki T, Yoshida N, Nakagawa H, Ogura M, Makishima M, Miyata N. Synthesis and evaluation of 2-nonylaminopyridine derivatives as PPAR ligands. Chem Pharm Bull 55: 1053-1059, 2007
Noguchi-Yachide T, Aoyama A, Makishima M, Miyachi H, Hashimoto Y. Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors. Bioorg Med Chem Lett 17: 3957-3961, 2007
Inaba Y, Yamamoto K, Yoshimoto N, Matsunawa M, Uno S, Yamada S, Makishima M. Vitamin D3 derivatives with adamantane or lactone ring side chains are cell type-selective vitamin D receptor modulators. Mol Pharmacol 71: 1298-1311, 2007
Kainuma M, Makishima M, Hashimoto Y, Miyachi H. Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist. Bioorg Med Chem 15: 2587-2600, 2007
Igarashi M, Yoshimoto N, Yamamoto K, Shimizu M, Ishizawa M, Makishima M, DeLuca HF, Yamada S. Induction of a highly potent vitamin D receptor antagonist: (25S)-26-Adamantyl-25-hydroxy-2-methylene-22,23-didehydro-19,27-dinor-20-epi- vitamin D3 (ADMI3). Arch Biochem Biophys 60: 240-253, 2007
Kawai M, Namba N, Mushiake S, Etani Y, Nishimura R, Makishima M, Ozono K. Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARγ pathway. J Mol Endocrinol 38: 19-34, 2007
Koike T, Uno S, Ishizawa M,Takahashia H, Ikeda K, Yokota S, Makishima M. The heat shock protein inhibitor KNK437 induces neurite outgrowth in PC12 cells. Neurosci Lett 410: 212-217, 2006
Kasuga J, Yamasaki D, Araya Y, Nakagawa A, Makishima M, Doi T, Hashimoto Y, Miyachi H. Design, synthesis, and evaluation of a novel series of alpha-substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonists for the treatment of metabolic syndrome. Bioorg Med Chem 14: 8405-8414, 2006
Hosoda S, Tanatani A, Wakabayashi K, Makishima M, Imai K, Miyachi H, Nagasawa K, Hashimoto Y. Ligands with a 3,3-diphenylpentane skeleton for nuclear vitamin D and androgen receptors: Dual activities and metabolic activation. Bioorg Med Chem 14: 5489-5502, 2006
Kainuma M, Kasuga J, Hosoda S, Wakabayashi K, Tanatani A, Nagasawa K, Miyachi H, Makishima M, Hashimoto Y. A diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands. Bioorg Med Chem Lett, 16: 3213-3218, 2006
Yamamoto K, Abe D, Yoshimoto N, Choi M, Yamagishi K, Tokiwa H, Shimizu M, Makishima M, Yamada S. Vitamin D receptor: ligand recognition and allosteric network. J Med Chem 49:1313-1324, 2006
Uno S, Dalton TP, Dragin N, Curran CP, Derkenne S, Miller ML, Shertzer HG, Gonzalez FJ, Nebert DW. Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Mol Pharmacol 69: 1103-1114, 2006
Uno S, Makishima M. Regulation of xenobiotic metabolism by xenobiotic receptors and cytochrome P450 enzymes. Nihion Univ J Med 47: 69-79, 2005
Kasuga J, Makishima M, Hashimoto Y, Miyachi H. Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists. Bioorg Med Chem Lett 16: 554-558, 2006
Morita K, Kawana K, Sodeyama M, Shimomura I, Kagechika H, Makishima M. Selective allosteric ligand activation of the retinoid X recetpor heterodimers of NGFI-B and Nurr1. Biochem Pharmacol 71: 98-107, 2005
Nakano H, Matsunawa M, Yasui A, Adachi R, Kawana K, Shimomura I, Makishima M. Enhancement of ligand-dependent vitamin D receptor transactivation by the cardiotonic steroid buffalin. Biochem Pharmacol 70: 1479-1486, 2005
Nishida S. Metabolic effects of melatonin on oxidative stress and diabetes mellitus. Endocrine 27: 131-136,2005
Fukuen S, Iwaki M, Yasui A, Makishima M, Matsuda M, Shimomura I. Sulfonylurea agents exhibit peroxisome proliferator-activated receptor gamma agonistic activity. J Biol Chem 280:23653-23659,2005
Noguchi T, Shinji C, Kobayashi H, Makishima M, Miyachi H, Hashimoto Y. Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites. Biol Pharm Bull 28: 563-564, 2005
Adachi R, Honma Y, Masuno H, Kawana K, Shimomura I, Yamada S, Makishima M. Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative. J Lipid Res 46: 46-57, 2005
Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114: 1752-1761, 2004
Uno S, Dalton TP, Derkenne S, Curran CP, Miller ML, Shertzer HG, Nebert DW. Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible CYP1A1 more important than metabolic activation. Mol Pharmacol 65: 1225-1237, 2004
Uno S, Dalton TP, Sinclair PR, Gorman N, Wang B, Smith AG, Miller ML, Shertzer HG, Nebert DW. Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intra-hepatocyte lipid accumulation and uroporphyria. Toxicol Appl Pharmacol 196: 410-421, 2004
Nishizawa H, Matsuda M, Yamada Y, Kawai K, Suzuki E, Makishima M, Kitamura T, Shimomura I. Musclin, a novel skeletal muscle-derived secretory factor. J Biol Chem 279: 19391-19395, 2004
Adachi R, Shulman AI, Yamamoto K, Shimomura I, Yamada S, Mangelsdorf DJ, Makishima M. Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals. Mol Endocrinol 18: 43-52, 2004
