Nihon University School of Medicine

Japanese

Faculty of Medicine

Clinical Medicine

Department of Internal Medicine

Division of Respiratory Medicine

We are mainly researching on allergic airway disease, lung cancer and inflammatory diseases. Furthermore, our research is also underway in the areas of sleep apnea syndrome and psychosomatic medicine. Since resolving fundamental issues has significant potential for aiding development of future therapies, we ensure that each member should work on both the basic and clinical research. Learning fundamental knowledge and concepts is essential for doctors at a university hospital who pursue a specialty. We also believe that collating research questions that arise in daily medical practice and tackling these questions using appropriate clinical research is a requirement for doctors.
Our research covers a diverse range of areas, including genes, cells, and animal testing using various laboratory instruments. Our research meeting is held every week to actively discuss the progress of experiments, problem areas, and interpretation of various issues.

Division of Cardiology

A mission of the department is to provide suitable treatment for cardiovascular disease including ischemic heart disease, arrhythmia, heart failure, cardiomyopathy, valvular heart disease, aortic disease, pulmonary vascular disease, and hypertension. The department is composed of research groups specializing in catheter intervention, catheter ablation, device treatment (CRT: cardiac resynchronization therapy, ICD: implantable cardioverter-defibrillator), management of heart failure, and noninvasive imaging to research the wide range of basic studies in animal models with atherosclerosis to clinical studies into the frontiers of catheter or device treatment and imaging evaluation of ischemic heart diseases and arrhythmia.
Main research programs in the department are as follows:

  • studies on arteriosclerosis in large animals with coronary artery unstable plaque
  • studies on 3-dimentional intravascular imaging flow analysis to clarify pathogenesis of acute coronary syndrome
  • studies on bio-markers predicting progression of arteriosclerosis
  • studies on effectiveness of cryoballoon ablation in treating atrial fibrillation
  • registry to identify Japanese concealed atrial fibrillation (REAL AF study)
  • studies on appropriate introduction and management of non-drug therapy for chronic heart failure
  • studies on ischemic evaluation and cardiovascular event risk with nuclear cardiology.
Division of Gastroenterology and Hepatology
Liver team:
We are working on analysis of the relationship between hepatitis viruses and the hepatopathology, clinical study of interventional radiology (IVR) for hepatocellular carcinoma and portal hypertension, and analysis of ultrasound images.
Gastrointestinal (GI) tract team:
We are engaging in clinical studies of diagnosis and endoscopic resection, especially endoscopic submucosal dissection (ESD) for esophageal cancer, gastric cancer, and colon cancer in the GI field. We are also focusing on research and treatment of chronic diseases (such as inflammatory bowel disease), infections (such as Helicobacter pylori-induced gastritis, and enteritis), and functional gastrointestinal disorders.
Gallbladder and pancreas team:
We are conducting clinical studies of diagnosis and treatment of biliary and pancreatic diseases, including gallbladder and pancreatic tumors, cholangitis, choledocholithiasis, IgG4-related disease, and acute and chronic pancreatitis. Meanwhile, we are performing an industry-university joint research for development of new types of endoscope and device to prevent pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). Regarding endoscopic ultrasound (EUS), we are also advancing an industry-university joint research and collaboration with basic medical course for development of new types of EUS image analysis software, tumor-specific diagnostic marker and treatment for pancreatic cancer, and molecular imaging techniques.
Division of Neurology
Clinical services
are offered by a full spectrum of divisions and programs within the division including: general neurology, epilepsy, stroke and neurological emergency care, movement disorders, memory disorders, neuro-immunology-multiple sclerosis, neuromuscular disease, neuro-oncology, headache, autonomic disorders and intraoperative monitoring. Our division provides care and consultative services to many patients referred from throughout Japan.
Research in the Division of Neurology
covers a wide range of multidisciplinary programs ranging from basic neuroscience studies, preclinical studies and clinical trials. In addition, our division is well known as the opinion leader of clinical management for Neuroinfections including encephalitis and meningitis in Japan.
  1. Ogawa K, Suzuki Y, Takahashi K, et al: Clinical study of seven patients with infarction in territories of the anterior inferior cerebellar artery. Journal of Stroke and Cerebrovascular Diseases, 26(3):574-581, 2017.
  2. Takahashi T, Tamura M, Takasu T, et al: Clinical and quantitative analysis of patients with crowned dens syndrome. Journal of the Neurological Sciences 376 52–59, 2017.
  3. Hara M, Ariño H, Petit-Pedrol M, et al: DPPX antibody-associated encephalitis: main syndrome and antibody effects. Neurology. 88(14):1340-1348. 2017.
Division of Hematology and Collagen Disease
Hematology & Oncology

Tumorgenesis, prognostic factors, and establishment of new treatment are focused.

Lymphoma:
new prognostic factors and stratified intensive chemotherapy.
Leukemia:
central role for several multicenter trials
RHEUMATOLOGY

In clinical research, cardiac involvement may have serious consequences and can contribute to worsening of a patient’s morbidity and mortality, in rheumatic disease (RD). Our research revealed subclinical cardiac involvement in RD, using a cardiovascular magnetic resonance.
In basic research , Epstein-Barr virus (EBV) has been implicated in the pathogenesis of rheumatoid arthritis (RA) on the basis of indirect evidence.
Our research revealed development of erosive arthritis closely resembling RA in humanized mice inoculated with EBV.

SELECTED PUBLICATIONS
  1. Miura K, Takahashi H, Hatta Y et al. Clinical significance of co-expression of MYC and BCL2 protein in aggressive B-cell lymphomas treated with a second line immunochemotherapy..
    Leukemia & Lymphoma. 2016; 57 (6) : 1335-41.
  2. Iriyama N, Hatta Y, Takei M. ETV6/ARG oncoprotein confers autonomous cell growth by enhancing c-Myc expression via signal transducer and activator of transcription 5 activation in the acute promyelocytic leukemia cell line HT93A.
    Leukemia & Lymphoma. 2015; 56 (8) : 2416-23.
Division of Nephrology, Hypertension and Endocrinology

We are currently focusing on the following areas.

  • Clinical research on diabetic nephropathy, renal anemia, mineral and bone disorder, cardiovascular disease, and drug therapy in patients with chronic kidney disease (CKD).
  • Research of novel therapeutic options for diabetic nephropathy and diabetic kidney disease.
  • Development of novel therapies for chronic kidney disease.
  • Research of microcirculating system and hemodynamics in the kidney.
  • The studies of primary and secondary kidney diseases, particularly on minimal change nephrotic syndrome, IgA nephropathy, lupus nephritis, and ANCA-associated glomerulonephritis.
  • Research of mechanisms for “Cardio-renal connection”
  • Development of novel renal replacement therapy and biocompatible dialysate for patients with acute kidney injury and maintenance hemodialysis.
  • We developed and reported PI polyamides targeting ABCA1, Sar1b, LOX1, TGF-β, and CTGF as novel gene-regulating agents.
Division of Diabetes and Metabolism

We have taken care of approximately 4,000 patients with diabetes and related metabolic disorders. Based on the clinical experience, we are seeking ultimate cure of patients with metabolic disorders and conducting research projects focused on the following topics:

  1. Molecular mechanisms of nutrient-stimulated insulin and glucagon secretion from pancreatic islets of Langerhans.
  2. Mechanisms of stress-induced pancreatic β-cell loss: special interests in roles of lncRNAs.
  3. Mechanisms of incretin secretion and its modulation by anti-diabetic drugs.
  4. Engineering of insulin secreting cells, including human iPS derived β-cells.
  5. Epidemiological analyses of the various effects of drugs for nutrient metabolism disorders.
Division of General Medicine

Research focuses of the Division of General Medicine are genetic epidemiology, infectious disease control, basic research for oncology, and the development of cancer therapeutics using Pyrrol Imidazole (PI) Polyamides. Topics are as follows;

  • Molecular genetic epidemiological research for common diseases and longevity.
  • Elucidation of the mechanism of metabolic abnormality with aging.
  • The survey for physical changes with aging and its related factors.
  • Epidemiological analysis and clinical significance for bacteria isolated in blood culture.
  • Evaluation of risk in the hospital infection.
  • Development of algorithm for the diagnosis among febrile patients.
  • Elucidation of a role of Hypertension-related, Calcium-regulated gene (HCaRG/COMMD5) in acute kidney injury, diabetic nephropathy and renal cell carcinoma, and its application for prevention and therapy of these diseases.
  • Searching and functional analysis of new tumor related genes.
  • Analysis of the epigenetic aberrances in tumors.
  • Development of the inhibitor of tumor specific transcripts, using sequence specific DNA binder PI polyamides.
  • Development of the DNA alkylating agent specific for tumors with fusion gene, using PI polyamides.

Department of Psychiatry

Division of Psychiatry

We provide the highest standard of psychiatric practice available now to those who suffer from psychiatric disorders, and conduct research activities for further development in psychiatry, which gives medical students and residents an opportunity to learn clinical practice and behavioral science in the field. Our research activity aims to clarify geneses of and to develop novel treatments for psychiatric disorders, by focusing on their psychopathology, cognitive state, sleep problems, biological rhythms and genetics basis. The following research projects are under way.

  • Study on relation between sleep habits and mood disorders
  • Development of sleep biomarkers for depressive disorders
  • Molecular genetics of schizophrenia and related disorders
  • Development of wake therapy for treatment-resistant depression
  • Visual cognitive process in psychiatric disorders
  • Study on psychological stress and psychiatric disorders

Department of Pediatrics and Child Health

Division of Pediatrics and Child Health

Our department have 12 sub-specialties as follows, Pediatric Neurology and Developmental Disorder, Pediatric Hematology & Oncology, Pediatric Nephrology and Rheumatology, Pediatric Cardiology, Pediatric Intensive Care (PICU), General Pediatrics, Neonatology, Pediatric Infectious Disease, Pediatric Allergy, Pediatric Lipid Metabolism and Obesity, Pediatric Endocrinology and Diabetes and Inherited Metabolic Disease. In cases of very sick children, we organize trans-disciplinary team with the above specialties to treat children. We also have eleven satellite hospitals where young doctors can experience all the diseases required for the examination of pediatric specialist. We also promote and empower clinical research as well as basic research for all the members of pediatrics. We have fourteen postgraduate students who are studying within our department or collaborating with Division of Microbiology and Division of Cell Regeneration and Transplantation. Our department choose and promote excellent young doctors to go abroad to study basic research. Actually, we have relationships with Department of Pediatrics and Department of Hematology & Oncology, Harvard medical school. With this relation, one of our member is now working at MGH and the other is supposed to work at Dana-Farber Cancer Institute in this fall.

Department of Dermatology

Division of Cutaneous Science

Our research mainly focuses on psoriasis and urticaria.
Psoriasis is an intractable inflammatory skin disease. Recently, the role of intestinal flora in the pathophysiology of various diseases has gained much attention, and the aim of our study is to characterize intestinal flora of patients with psoriasis and investigate how their intestinal flora affect the immunological status of the psoriasis patients.
Mast cells play a critical role in urticaria. We are currently analyzing its pathogenesis focusing on a relationship between mast cells and autoantibodies or neuropeptides for the development of novel therapeutic strategy.

  • Analysis of intestinal flora of the patients with psoriasis
  • Expression and function of Mas-related gene X2 on human skin mast cells in chronic spontaneous urticaria patients
  • Clinical relevance of autoantibodies found in patients with chronic spontaneous urticaria
  • Roles of neuropeptides in chronic spontaneous urticaria
  • Comparison of basophil activation through IgE-dependent stimulation between chronic spontaneous urticaria patients and non-atopic controls

Department of Surgery

Division of Digestive Surgery

In our department, digestive surgery field, especially surgical treatment of liver cancer is the most in Japan and is one of the world leading facilities. Surgical treatment and anticancer drugs treatment for gastrointestinal cancers are also active. We are conducting basic research including genetic search as well as clinical research using randomized controlled trials.

  • Systematic vs local resection for hepatoma(n = 450)
  • Surgery vs radiofrequency for hepatoma(n = 500)
  • Film-coating for resected liver stumps (n = 1,000)
(Representative paper)
  1. Sakuramoto S, Fujii M, et al. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med. 2007; 357:1810-20.
  2. Totoki Y, Takayama T, et al. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes. Nature Genet. 2014; 46:1267-73.
  3. Bruix J, Takayama T, et al. Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation. Lancet Oncol. 2015; 16:1344-54.
Division of Cardiovascular Surgery

A year has passed since Dr. Masashi Tanaka was appointed as a chief professor and started his new clinical works and researches. More than 600 cardiovascular surgery operations are performed per year with favorable outcome, and also our department, as a university, has several researches ongoing to improve surgical outcomes.

Clinical researches
  • Assessment and management of post fluid retention following cardiac surgery; prevention for postoperative atrial fibrillation
  • Elucidation of appropriate surgical procedure for acute aortic dissection
  • Analysis of etiology and risk factors of abdominal aortic aneurysm
  • Propagation of minimally invasive cardiac surgery (MICS) and innovation of less invasive surgery
  • Organizing medical team for proactive clinical induction of ventricular assist device (VAD)
Basic researches
  • Clarification of mechanism and signal transduction of cardiac ischemic reperfusion injury using transgenic mouse
  • Analysis of graft blood flow pattern on different pathophysiology in coronary artery bypass graft surgery
  • Assessment of changes in hemodynamics and organ perfusion following ventricular assist device (VAD)
  • To elucidate mechanism of aortic rupture following acute aortic dissection based on immune response analyzation
  • Studying the effect and cardiac restoration of several type of stem cell transplantation for ischemic cardiomyopathy
  • Investigating efficacy of autologous differentiated fat cell (DFAT) transplantation for critical limb ischemia
Division of Respiratory Surgery

The Division of Respiratory Surgery deals with various kinds of neoplasms and associated diseases in the thorax, with the exception of the esophagus. These include both primary and metastatic lung tumors, mediastinal tumors, pleural tumors (mesotheliomas), chest wall tumors, pneumothorax, and inflammatory disease. The main clinical activity of the division, as well as the subject of most of its research activities, has been the surgical management of lung cancer patients. In addition to efforts to further improve procedures, such as the combined resection of neighboring vital structures and minimally invasive techniques (video-assisted thoracic surgery, VATS), it has become increasingly important to define the role of surgery in multimodality treatment for patients with a poor prognosis.

  • Sublobar resection for early-stage lung cancer.
  • Clinical trial of adjuvant chemotherapy for resected pathological stage I non-small lung cancer
  • Diagnostic utility of FDG-PET for mediastinal tumor.
  • Opitimal distance of surgical margin in limited resection for pulmonary malignancy.
  • Prevention of recurrent spontaneous pneumothorax.
  • Prospective malignant pleural mesothelioma registry study.
Division of Pediatric Surgery

The Department of Pediatric Surgery at Nihon University provides general surgical cares and pursues researches in the field of infants and children. Our priority is to provide safe health care without anxiety. Our team is specialized exclusively in newborn and oncologic surgery with professional expertise of other allied specialties. We have recently started to cover pediatric urologic surgery again for pediatric surgical babies. Our focus has been minimally invasive surgery for more than twenty years. We have performed more than 400 surgical operations in a year, achieving good results as well as in premature babies and the children with underlying disorders. As medical researches, our interest and publications are the following areas:

  • Discovery of a new oncogene of pediatric malignant solid tumor.
  • Role of differentiation and promotion of pediatric tumor.
  • Cell-regeneration using DFAT (de-differentiated fat cell).
  • Making model mice of pediatric surgical disease.
  • Applying of Kampo medicine for pediatric surgical disease.
  • Development of new nutritional therapy for pediatric surgical disease.
  • Clinical research of contralateral inguinal hernia in children.
  • Clinical research of interval appendectomy for appendicitis with abscess.
  • Clinical research of surgical procedures for pediatric urologic disease.
Division of Mammary Gland and Endocrine Surgery

Our division specializes in surgical treatment and oncology for mammary and endocrine diseases such as breast cancer, benign breast disease, thyroid cancer, benign thyroid disease, and parathyroid disease. Especially breast cancer has increased in recent years. We perform clinical studies on surgical therapy, endocrine therapy, and chemotherapy for breast and thyroid cancer, and basic research on the immunological escape mechanism of cancer..

Clinical studies
  • Breast cancer operation considering tolerability and curability
  • Treatment to reduce metastasis / relapse rate of breast cancer
  • Intra-ductal diagnosing with ductal endoscope
  • Thyroid operation to reduce complications
  • Treatment aimed at improving the prognosis of elderly cancer
Basic research
  • Elucidation of the immunological escape mechanism of breast cancer
  • Elucidation of the Epithelial-mesenchymal transition of breast cancer
  • Molecular pathological analysis about the relationship of inflammation and cancer
  • Development of breast cancer treatment targeting the regulation of cell cycle
Division of General Surgery

The Division of General Surgery provides the education and training that is required for general surgeons to obtain the necessary basic clinical skills. The Division of General Surgery aims to comprehensively develop clinical, research, and educational skills. We also conduct studies, ranging from fundamental investigations to clinical trials, primarily on the cardiovascular system, artificial organs, and the digestive system.

Department of Plastic and Reconstructive Surgery

Division of Plastic and Reconstructive Surgery

In our department, we are engaged in divergent treatments and clinical studies including traumas of face/limbs and reconstruction after tumor resection by cooperating with various related departments. We conduct clinical studies aiming at the innovation of the conventional therapy and the development of the new trauma therapy. (1) early burn wound excision for severe burn, (2) development of the new adjuvant therapy of the cultured epidermal autograft by micro skin graft, (3) development of the semi closed reduction method which minimized invasion for the zygoma fracture, (4) development of the therapy using the balloon for the orbital bone fracture. In Nihon University, we established methods of isolation and culture of dedifferentiated fat cells (DFAT) that have characteristics similar to those of mesenchymal stem cells. Currently, we are collaborating with Division of Cell Regeneration in multiple fields. We are engaged in basic research aiming at clinical application of DFAT, including (5) development of a new artificial skin combining the artificial dermis and DFAT, (6) examination of skin engraftment promoting action of DFAT in skin graft, (7) examination of action of DFAT to promote engraftment of the cultured autologous epidermis, (8) examination of the effect of DFAT to prolong duration of engraftment in skin allograft, and (9) examination of the effect of DFAT to enlarge the flap engraftment area.

Department of Neurological Surgery

Division of Neurosurgery

Since the establishment of our department, we have been working in three main fields: education, research, and clinical practice. In addition, we are proud that our staff are world class professionals in their fields. Neurosurgery is further divided into three major areas: tumor, vascular disease, and others. Others include functional surgery, spinal surgery, children, and trauma. With the idea that a neurosurgeon should also be a scientist, we are focusing not only on clinical research but also on basic research. Our research areas include tumors, trauma, vascular diseases, and functional diseases. All staff members are dedicated to their fields.

Department of Orthopaedic Surgery

Division of Orthopaedic Surgery

Clinic and research about the locomotory disease of spine and extremities' bones and joints were performed. We performed more than 1,200 patients with the locomotory disease of spine and extremities' bones and joints per year. And we accomplish it from fundamental researches to clinical studies widely at the same time.

  • Development of new spinal instrumentation
  • Prediction of prognosis for the metastatic spine tumor
  • Alarm for the spinal paralyses due to epidural spinal cord compression of the spine tumors
  • Prevention for the fragile fractures due to osteoporosis
  • An intervertebral disk regeneration using the dedifferentiation fat-cell
  • New prosthetic development
  • A mast cell in the synovium and the inflammation
  • The gene and custom-made treatment for malignant bone and soft tissue tumor
  • The optimal treatment for the childhood malignant bone tumor
  • A sport ligamentous injury of the knee
  • The elucidation of the pathologic condition in the entrapment neuropathy

Department of Obstetrics and Gynecology

Division of Obstetrics and Gynecology
[Clinical field and study]

Invasive cervical cancer occurs sometimes on reproductive young women and fertility is abrogated by the treatment (radiotherapy or surgery). However, we can preserve their fertility by special surgical treatment, named “trachelectomy”, which can preserve uterine body and ovaries removing cervical cancer lesions and surrounding tissues.

[Oncology]

We have developed a novel therapeutic immunotherapy targeting HPV molecule for treatment of cervical cancer and its pre-cancer lesion and will conduct a Phase I/II clinical trial of Lactobacillus-based HPV E7 molecule-targeting immunotherapy.

[Maternal-fetal medicine]

Placenta growth factor (PlGF) is one of angiogenic factor and soluble vascular endothelial growth factor receptor 1 (sVEGFR1) is one of antiangiogenic factor which regulates PlGF function. To elucidate the effects of cytokines and TLR ligands on the production of angiogenic and antiangiogenic factors in trophoblasts, we examined the production of PlGF and sVEGFR1 from trophoblasts following stimulation with cytokines and TLR ligands.

Department of Urology

Division of Urology

The research fields of Department of Urology include oncology, voiding dysfunction and female urology. The main research focus in urologic oncology is androgen receptors (AR) concerning the development and progression of prostate cancer which include establishment of a new therapeutic agent using PI polyamide. For the field of voiding dysfunction, on-going projects include fundamental experiments in neurogenic bladder and clinical investigation of male LUTS patients with α1 blockers, 5α-reductase inhibitor, PDE5 inhibitor and pollen lump extract and saw palmetto oil. With a high volume of surgical experience in the treatment of pelvic organ prolapse (POP), we apply core lower urinary tract symptom score (CLSS) for the evaluation of POP. Also, we started to apply robot-assisted laparoscopic prostatectomy (RALP) for patients with localized prostate cancer and accumulating experience for clinical study.

Department of Visual Science

Division of Opthalmology

Our research units aim for; 1) Refractory corneal diseases such as limbal stem cell deficiency and corneal ulcers, 2) retinal circulation disorders such as diabetic retinopathy, and 3) surgical and medical approaches for macular diseases such as age-related macular degeneration and retinal vascular occlusive diseases. We have organized the integration of basic researches such as molecular biological approach and genome analysis, educational research such as formulation of wet lab educational systems, and clinical research. Our final aims are to elucidate the molecular mechanisms of disease onsets and to provide the novel therapeutic methods of ophthalmic diseases.

  • Application of cultivated cell sheet for limbal stem cell deficiency
  • Formulation of animal keratoplasty model and elucidation of rejection mechanisms
  • Relationship between corneal disease and inflammasome
  • Novel therapeutic approach for the retinal diseases using porcine retinal arterioles
  • Investigations of safety and efficacy of ocular surface irrigation with 0.025% povidone-iodine during ophthalmic surgery
  • Clinical researches of anti-vascular endothelial growth factor treatment for age-related macular degeneration
  • Disease susceptibility gene analysis of age-related macular degeneration
  • Developing wet lab simulation courses for ophthalmic surgery using porcine eye

Department of Otolaryngology-Head and Neck Surgery

Division of Otolaryngology-Head and Neck Surgery

Our research foci are widely ranged, which include sensory organ research, research for voice and communication disorders, and basic and clinical cancer research. For instance, in the otologic area, wide variety can be seen. Acute otitis media is commonly seen on daily clinical practice. Eosinophilic otitis media is a refractory disease, the treatment of which has not yet been established. Moreover, temporal bone malignancy is rare with poor prognosis. We are always pursuing precise diagnosis and most appropriate treatment for such many kinds of diseases, and then are performing clinical researches, moreover, a variety of basic researches with collaboration.

  • Animal model for eustachian tubal closing failure
  • Regenerative medicine using DFAT
  • Expression of taste receptor genes in the taste papillae
  • Expression of cancer genes in suquamous cell carcinoma
  • Laryngeal tumor and human papilloma viruses
  • Regeneration and recovery for voice disorder
  • Mechanism of tinnitus in animal models
  • Generation and development of nasal polyp
  • High-speed video analysis of vocal cord movement
  • Facial nerve paralysis and viral infection
Division of Oral Surgery

In the presence, the elderly person has many teeth.
It is projected that elderly people increase drastically, in future years.
Therefore, the treatment and results of research of the oral disease are expected. We perform treatment and clinical examination for a various oral disease. Additionally, the fundamental researches of the gene therapy for the malignant tumor induced oral squamous cell carcinoma are developed.

  • Clinical statistics of oral tumour
  • Clinical statistics of oral inflammation
  • Clinical research of temporomandibular disorder
  • Clinical research of odontectomy
  • Clinical statistics of oral cacogenesis
  • Basic research of oral malignant tumor
  • Molecular biological research of Del1

Department of Radiology

Division of Radiology

On the division of diagnostic radiology, morphological and functional studies for several kinds of disorders and optimal acquisition methods are advanced in particular MRI. In addition, several quantitative researches with newly ongoing MR imaging biomarkers are conducted to add more clinical benefits. On the division of therapeutic radiology, optimal methods using radiation and anti-cancer agents for a variety of cancer diseases are developed. We also advance leading development of molecular-based anti-cancer radiation therapy combined with chemotherapeutic drug.

  • Analysis of gadoxetic acid disodium-enhanced MR imaging finding characteristics of cholagiolocellular carcinoma of the liver with histopathologic correlation.
  • Investigation of hepatic fibrosis staging and characterization of focal liver lesions using newly ongoing MR imaging biomarkers such as MR texture analysis or measurement of T1 rho value.
  • Utility of free breathing contrast-enhanced dynamic MR imaging using newly fast MR acquisition method (DISCO).

Department of Anesthesiology

Division of Anesthesiology

We anesthesiologists have investigated actions of the anesthetic drugs, physiological change in the organs during anesthesia, improvement of anesthetic techniques and monitoring methods to contribute to perioperative patient’s safety. In addition, we have engaged actively in study for release from various pain states.

  • Pharmacodynamics of neuromuscular blocking agents and the reversal drugs
  • Mode of action of the anesthetics and related drugs on neuromuscular junction
  • Development of effective neuromuscular monitoring unit
  • Cerebral circulation and oxygenation
  • Safety and neural toxicity of local anesthetics
  • Postoperative pain control
  • Ultrasound-guided neural blockade
  • Autonomic nervous activities in anesthetized patients and chronic pain patients
  • Multidisciplinary pain management - acute pain, intractable chronic pain, and cancer pain
  • Pain management in pain clinic

Department of Acute Medicine

Division of Emergency and Critical Care Medicine

Currently we focus on research, clinical practice, teaching, and training less experienced medical practitioners in general acute and intensive care medicine, covering a broad array of disciplines including pre-hospital emergency care and emergency care systems, disaster medicine, traumatology, sepsis, and toxicology.
We conduct research on emergency and critical care for pre-hospital and initial therapy and in the field of intensive care medicine. For the latter field, our research even covers: pathophysiological analysis and control of severe stress that occurs in severely traumatized or septic patients; comprehensive search for biomarkers associated with clinical outcomes of sepsis, cerebral infarction, and post cardiac arrest syndrome; establishing a nutrition therapy for critically ill patients; early brain function assessment method for post cardiac arrest syndrome patients; development of non-invasive cerebral protection devices (pulmonary cooling devices); and neurological intensive care, neurological monitoring and target temperature management.

Basic Medicine

Department of Functional Morphology

Division of Anatomical Science

Based on the macroanatomy, neuroanatomy, and microanatomy, we are studying the following research subjects. The hematopoietic microenvironment, which regulates hematopoietic cell proliferation and differentiation, image analysis of melanoma cells, the subependymal zone and the limbic system in the brain and the neural network formation, and clinical anatomy of the knee joint.

  • Development of a 3D artificial bone marrow system using polymer particles with grafted epoxy polymer chains
  • Analysis of hematopoietic supportive and protective functions of marrow stromal cells, an essential component of the hematopoietic microenvironment in aging, under biostress
  • Mechanism of arginine inducement in erythropoiesis
  • Molecular mechanisms and biological significance of anti-tumor agents against melanoma
  • Understanding of embryonic ependymal antigen-positive cells
  • Fine structure of subependymal cells
  • Functional anatomy of the limbic system, including the hippocampus, amygdala, and extended amygdala
  • Interaction between the olfactory and limbic systems
  • To alleviate stress responses, including several psychiatric diseases
  • Examination of cell type specification and axonal targeting projections
  • Analysis of the central and peripheral nervous systems using transgenic mice
  • Microstructural analyses using multiview imaging.
  • Anatomical studies of the anterior cruciate ligament (ACL), knee osteoarthritis morphology, and morphological variations of the meniscus
Division of Cell Regeneration and Transplantation

The mission of Department of Functional Morphology, Division of Cell Regeneration and Transplantation is to study stem cell-based regenerative medicine and molecular mechanisms of cardiovascular diseases based on stem cell biology and vascular biology. Currently, our research group focuses on developing practical cell-based therapies for various intractable disorders by collaborating with clinical colleagues of varying specialities. The themes we address include:

  • Development of cell-based therapy using dedifferentiated fat (DFAT) cells
  • Molecular mechanisms for cell differentiation/dedifferentiation
  • Molecular mechanisms for tissue regeneration
  • Basic research for fatal tissue-derived stem cells
  • Basic research for angiogenesis, atherosclerosis, and hypertension

Department of Biomedical Sciences

Division of Physiology

OOur research aim is to elucidate biological phenomena using cell biological methods and to apply the research results to clinical medicine.
We have proposed a novel subfamily of EGF motif. Recombinant proteins with this EGF motif induce apoptosis. Apoptosis induced by efficient gene therapy with the EGF motif improves prognosis in an explanted tumor mouse model.

Division of Biochemistry

We are investigating mechanisms of regulation of metabolism and immunity and pathogenesis of metabolic disease, immune and inflammatory disease and malignancy at molecular, cellular and animal levels. Specifically, we focus on molecular biology of nuclear receptors that regulate metabolism and immunity, such as vitamin D receptor (VDR) and liver X receptor (LXR), and molecular pathogenesis of hepatic cancer. We will develop novel diagnostic and therapeutic methods for related diseases.

  • Regulation of lipid metabolism and immunity by VDR and LXR in the liver and intestine
  • Molecular basis of function-selective VDR ligands and its application to drug discovery
  • Analysis of function of the RORγ-interacting protein DCCR14
  • Metabolism of the xenobiotic benzo[a]pyrene and its relationship to human diseases
  • Molecular biology of development and recurrence of hepatic cancer
  • Immunology of hepatic cancer
Division of Pharmacology

We obtained the study data from electronic medical records stored in Nihon University School of Medicine (NUSM) Clinical Data Warehouse (CDW), which is a centralized data. Repository that integrates separate data bases, from the hospital information systems at three hospitals affiliated NUSM. The prescription database in CDW contains information from approximately 3 million patients, and prescribing data, which have been collected continuously since September 2004, are linked longitudinally to detailed clinical information such as patient demographics, diagnosis, and laboratory data.

Reference)
  1. A comprehensive analysis of association of medical history with airflow limitation: a cross-sectional study. International Journal of Chronic Obstructive Pulmonary Disease. 2017.
  2. Comparative effect of calcium channel blockers on glomerular function in hypertensive patients with diabetes mellitus. Drugs in R&D. 2017.

Department of Pathology and Microbiology

Division of Human Pathology

Cardiovascular and Neurological Pathology, From Bench to Patients

Our research focus:
  1. Vascular biology, to overcome atherosclerosis

    Studies focusing on the pathogenesis of atherosclerosis, particularly on the modulation of vascular smooth muscle cell phenotype in the vessel wall were carried out. We have discovered several key factors, which control the smooth muscle cells biology. These factors might be one of the therapuitic targets for atherosclerosis, the root cause of cerebral and cardiovascular diseases.

  2. Cardiac pathology

    We discovered several factors related to cardiac remodeling after myocardial infarction. Furthermore, regenerative medicine for cardiac failure after myocardial infarction using mesenchymal stem cell was examined.

  3. Neuropathology

    We are also interested in neurodegenerative disease and brain tumors. To date, we reported the correlation between dementia and the medial temporal neuropathological features among the patients with Parkinson’s disease. Furthermore, we reported cases of various primary brain tumors.

Division of Morphological and Functional Pathology

We have been conducting research on liver diseases, especially viral hepatitis, cirrhosis and hepatocellular carcinoma (HCC), carrying forward the work of emeritus professor Toshio Shikata. Our recent research has focused mainly on molecular analysis of the hepatitis C virus (HCV) in chimpanzee experiments and human samples, epidemiological survey and immuno-molecular analysis of hepatocellular adenoma (HCA), molecular research in HCC, immuno-pathological studies of acute rejection in liver transplantation, investigating Bangladesh hepatitis, and clinic-pathological research in malignant lymphoma, bone and soft tissue neoplasms, and inflammatory bowel diseases.

Division of Oncologic Pathology

To serve functional roles between clinical and basic research will stimulate the development of pathology. Observation of pathological findings means to investigate molecular events actually occurring in the patient body that enable us to understand the disease comprehensively. The aim of our department is to resolve research questions raised in the clinicopathological activities.

  • What kinds of mechanism regulate proliferation of hormone independent cancer cells?
  • How apocrine carcinoma cells are proliferating?
  • Do carcinoma cells of combined ductal and lobular carcinoma originated from identical cells?
  • Are carcinoma cells of tumor consisting of different histological types originated from different cell?
  • How lung cancer cells become to be resistant to targeted therapies?
  • What are biological significance of expression of glycoprotein on the surface of carcinoma cells?
  • What can we do to treat pediatric cancers effectively?
  • What kinds of system do we need to control and assure the quality of pathological diagnosis?
Division of Microbiology

The mission of our division is to provide comprehensive scientific instruction of medical microbiology, clinical immunology and infectious disease control to both undergraduate and postgraduate medical students through rigorous coursework and advanced research opportunities. We provide an exceptional research environment including biosafety level (BSL)3 rooms and training courses for postgraduate students want to obtain Ph.D. degree. Researches underway in our department involve the maternal-fetal relationships and vertical infection control including HIV, influenza, rubella and other viral diseases, molecular epidemiology of pediatric viral infections including rotavirus, norovirus RS virus etc, in South East Asian countries. We also investigate diverse immunological topics such as molecular design of novel anti tuberculosis vaccines, local immune responses in reproductive organs and digestive tract from oral cavity to rectum in relationships with medical/dental/gynecological disorders.
In the past 10 years, we have accepted young scientists from many departments of clinical medicine as well as other schools of Nihon University, University of Tokyo, Saitama Medical University as post graduate students or post-doctoral fellows including JSPS fellowship. We also practice international collaboration between foreign scientists in USA, Thailand, Taiwan, Vietnam, Korea, Lao PDR, Bangradesh under official grants including JICA and NIH grants and published at least 12 refereed articles every year in English.

Division of Laboratory Medicine

We can utilize a wide field of the clinical laboratory such as big data every clinical inspection including a laboratory determination, examinations of physiology. We have constructed to perform the research system to be able to keep the expertise of each member of the division. Our division is the environment that is easy to act for women person with the child care. We are collaborating the study with the many other medical divisions.

  • Isolating novel mutations of many monogenic diseases
  • Genetic testing and Genetic counseling
  • Isolating novel susceptibility markers of multifactorial disorders
  • Relation between the complement and diseases
  • Automated systems for routine blood transfusion tests
  • Evaluation of the vascular endothelial and smooth muscle cell function using ultrasonography
  • Zoonosis, Q fever, Pasteurellosis
  • Development of isoenzymes (CK, ALP, LD, AMY) analysis.
  • Oxidative stress and organ damages
  • MYC and BCL2 gene in patients with advanced diffuse large B-cell lymphoma

Department of Social Medicine

Division of Hygiene

The main research interest of our division is Space Medicine. We are currently conducting several projects that investigate astronauts who stay on the International Space Station before, during and after spaceflight at the NASA space center. Also, effects of various gravity on circulatory system are investigated in our laboratory at Itabashi by using a human centrifuge. A major focus is on the ability of the circulatory system to regulate brain blood flow, intracranial pressure, and arterial blood pressure. In these projects, we have been using measurements of cerebral blood flow in the middle cerebral artery by transcranial Doppler sonography, continuous arterial blood pressure, and ECG in order to non-invasively estimate cerebral autoregulation, intracranial pressure, and arterial cardiac baroreflex. In addition to space medicine research, by using these experimental techniques, our research team investigate effects of hypoxic hypoxia, high altitude training and perioperative environment.

Division of Public Health

Division of Public Health, Department of Social Medicine, School of Medicine, Nihon University is one of the first five research laboratories established under the guidance of GHQ in Japan in 1948. It was the first laboratory at a private university to carry out epidemiological research on tuberculosis, the leading cause of death at that time. Our laboratory provided results as basic data for tuberculosis prevention measures for the Japanese government.
Currently, we are providing basic data on health problems in Japanese minors in order to establish the “Health Japan 21” by the Ministry of Health, Labour and Welfare. The following are the main areas of study.

  1. Carry out an epidemiology survey on health problems in minors throughout Japan, and reflect the results in the government health policy.
  2. Survey smoking related issues among medical related personnel in Japan, and aim to reduce the smoking rate.
  3. Survey sleeping related issues among workers, and plan health countermeasures.
Division of Legal Medicine

The aim of legal (forensic) medicine is solve various legal problems using the medical knowledge and technology. That representative is investigating the cause of death. Forensic autopsy against suspicious death of a person and trying to identify the cause of death by doing diagnostic imaging, alcohol and various drug toxic analysis etc. in parallel. We are also focusing on the diagnosis and prevention of child abuse that is a social problem. It also supports DNA identification from all forensic scientific samples such as blood, saliva, semen, bloodstains, hair, nails, bones, etc., and also carries out individual identification and paternity test.

  • Forensic image diagnosis (especially, ultrasound applications)
  • Postural asphyxia (Positional asphyxia)
  • Long-term preservation method of corps (application of electromagnetic waves and ozone)
  • Epidemiology and diagnosis of child abuse, prevention activities as forensic medicine
  • Detection of plankton DNA from organs of drowning by direct PCR method and diagnosis of drowning
  • Detection and personal identification of STR polymorphism by direct PCR method from nail in large-scale disaster
  • DNA repair of analysis of STR polymorphisms from damaged forensic materials
  • Alcohol Metabolism and Mechanism
  • Relationship between causes of death and parasitic diseases
  • Medical safety management and forensic medicine
Division of Health Care Service Management

We conduct theoretical, empirical and heuristic research on ethics, social system, social environment, and information issues surrounding health and medical welfare. In the field of medical informatics, we are promoting research on medical records and clinic record issues. In the field of medical safety, we conduct various theoretical studies on causal classification of various errors occurring in the thought process by medical staff through actual case analysis of doctor's decision making process. In the field of medical sociology, we conduct empirical study on social determinants of health.

  • Theoretical research on overview description method of medical record
  • Analytical research on information multiplexing caused by multipurpose of medical practice
  • Survey analyses on health information literacy of patients and health care workers
  • Statistical analyses on establishment of prognosis prediction method for head injury
  • Time series analysis studies on thought process of medical staff
  • Analysis of error cases in decision making process by medical doctors
  • Case studies on influence of emotional factors on thought process of medical staff
  • Analysis of influence of value bias on thinking process of medical staff
  • Analysis of effects of social structure and socioeconomic anxiety on health outcome

Liberal Arts

Liberal Arts

Division of Psychology

Psychology is scientific research of the mind and learns how it affects people's behavior.

Field area of education and research
  • Clinical psychology
  • Psychotherapy
  • Mind-body correlation
  • Transactional analysis
  • Autogenic training
  • Behavior therapy
  • Relaxation
Division of Bioethics

We are responsible for a course on bioethics focusing on medical ethics for first year undergraduates, and are studying research ethics. Additionally, our biological research involves the comparative immunology of ascidians.

  • Research ethics: the causes of scientific misconduct.
  • Self-nonself recognition system of ascidian hemocytes.
  • ‘Soft tunic syndrome’ in the ascidian species Halocynthia roretzi.
  • Study of the fine structures of ascidian hemocytes in Halocynthia roretiz, using cryotechnology.
Division of Physics

Focused on our academic core area of Materials Science, we study about physical properties of functional materials such as superconductors, photo-induced molecular magnets and ferroelectric oxides. We have also started collaboration with other divisions in School of Medicine, where we focus on the development of cutting-edge sensing techniques of neoantigens that have attracted considerable research interests as targets of cancer immunotherapy.

Division of Chemistry

Two main fields are studied in the Division of Chemistry. One is the design of functional materials, including metallic organic materials, nanoalloys and metal-organic frameworks, all of which have attracted much attention as next-generation materials. First-principles calculations are used to clarify the origin of the functionalities at the molecular levels. The other is an enantioselective isolation of chiral polyoxometalates (POMs). Chiral POMs are expected to play important roles in fields like catalysis, luminescence, non-linear optics, and inorganic medicine. Weak interactions of amino acid, peptide, and ATP etc. to chiral POMs are effective for the enantioselective isolation and we utilize them as chiral auxiliary.

  • Design of Novel Superconductors
  • Design of Metal-Organic Frameworks
  • Development of a method for enantioselective isolation of chiral POMs
  • Exploration of novel properties of chiral POM
Division of Biology
  • Comparative immunology: Studies on the protective response of Ascidiacea (sea squirt), properties of the protease inhibitor, and the phenol oxidase inhibition. Identification of mycosporin-like amino acids containing in symbionts of colonial ascidians.
  • The degeneration of somatostatin neurons and amyloid beta aggregation, which are thought to have a relationship with Alzheimer disease.
  • Motor cortex stimulation therapy for thalamic pain and deep brain stimulation therapy for Parkinson disease.
  • Drug administration for prevention of neuronal cell death after Ischemia
  • Neural cell death and neurogenesis after brain damage
  • Stereoscopic visual system in the primate
  • Neuronal development and aging of the primate
  • von Economo neuron and social behavior of the primate and human
Division of Mathematics

In our division, there are 2 main areas of research, education and pure mathematics. Our educational research focuses on the development of more effective e-learning activities :

  • Developing learning activities using the Stack system inside Moodle.
    Regarding our research into pure mathematics, we are currently investigating geometric structures which are determined by the solution of certain partial differential equations(PDE). This investigation requires expertise in the following research fields :
  • Integrable Systems
  • Global Analysis
  • Differential Geometry

In case of the existence of some surface in space, it is the case of realization of the solution of PDE, which is called “Integrable Systems”. The realization of the surface in space, for example, soap bubble, means the surface is stable among the variations. To search for the stable solution is the main achievement of “Global Analysis”. “Differential Geometry” provides the fundamental tools for analyzing those problems mentioned above. It is commonly known that Albert Einstein used Differential Geometry to elucidate his theory of general relativity.

Departments/Divisions Directly under the Control of the Dean

Center for Institutional Research and Medical Education (Medical English)

NUSM medical English instructors are all members of the Center for Institutional Research and Medical Education. As such, our research focuses on English communication for medical purposes, but the underlying ethos is pedagogically motivated. Examples of research topics that will illuminate a path forward for better, more efficient and effective teaching include the following:

  • Corpus linguistics research into characterizing the features of medical research article writing
  • Corpus linguistics research into characterizing the features of doctor-patient conversations
  • Quantitative and qualitative mixed conversational analysis and corpus linguistics research methods to compare how patient-centeredness is expressed by doctors and students
Division of Medical Research Planning and Development

The Research Planning and Development Medical Research Support Center was established in 2006 to manage and operate experimental apparatuses and facilities for joint use, which is important to promote basic and clinical studies in the Nihon University School of Medicine, realize basic study achievements in clinical studies, and support basic experiments to solve questions that arise in clinical studies. The objective of our laboratory is to promote and develop basic and clinical studies in the School of Medicine, for which we are required to be well-acquainted with basic and clinical studies.
Currently, our laboratory performs studies centering in translational research aiming at the diagnosis, identification of the pathology, and treatment of digestive diseases. Basic and clinical studies are designed based on the achievements concerning digestive diseases determined by biological and medical statistics, simple test methods are developed, and clinical studies on new treatment methods are performed.

Division of Epidemiology and Medical Statistics

We are currently pursuing research into mathematical statistics, medical statistics and clinical statistics. With respect to mathematical statistics, we are particularly interested in the following:

  • Information Geometry.
    We are attempting to develop a general theory for the best method of providing an information metric and a maximum likelihood estimator on a statistical manifold. For medical and clinical statistics, we are investigating improved methods of solving statistical problems which are particularly salient to graduate students and clinicians using the computer softwares SPSS, EZR and SAS.

Division Established by an Adjunct Professor Externally Funded Courses

Division of Cellular and Molecular Pharmacology

We are studying the basic principles of calcium signaling, the fundamental signal transduction mechanism of life. Based on such studies, we are searching for new functions of calcium signaling in our body, and are aiming at shedding new light on biological functions using innovative imaging methods.

Outline of our research on calcium signaling
  • Elucidation of basic principles of calcium signaling
  • Search for new functions of calcium signaling
  • Functional analyses of various cells using imaging methods of signaling molecules
Division of Advanced Cardiovascular Imaging

Intravascular imaging is a technology that uses a very fine catheter with a diameter of approximately 1mm, the tip of which can emit and receive ultrasound or light signals to be able to visualize the condition of atherosclerotic arterial wall in vivo. In this department, the following researches especially in the field of basic or clinical studies on coronary artery disease are being enthusiastically performed.

  • Core laboratory image analyses of multi-center clinical trials.
  • Development of novel technology of intravascular tissue characterization
  • Studies of the effect of lipid-lowering drugs or anti-diabetic agents on atherosclerotic plaque in atherosclerotic humans, rabbits or pigs.
  • Analyses of macrophage accumulation or microvessel formation within plaque
  • Studies on the relationship between shear stress and plaque vulnerability
  • Development of new 3D or Virtual Reality imaging technologies.
  • Intravascular cellular or molecular imagings
  • Applications of non-obstructive aortic angioscopy.
Division of Research course for cancer prevention, screening and treatment of digestive tract, Department of Medicine

We are flattering ourselves to contribute to gastrointestinal cancer therapy on the advanced endoscopic diagnoses and treatment, especially endoscopic submucosal dissection. We have conducted with Yurihonjo and Nikaho cities in Akita prefecture, which are area with high incidence of gastrointestinal cancer, to make mutual collaboration for comprehensive medical care in gastroenterological field. The primary aim of our relationship is to bring admirable screening program for gastric cancer and earlier intervention of cancer prevention. Then, results of several ongoing studies are going to carry new administration plans.

  • New screening program for gastric cancer in decreasing Helicobacter pylori infection era
  • Chemoprevention for Helicobacter pylori infection in the junior high-school students
  • Changes of microbiota after Helicobacter pylori eradication in the junior high-school students
  • Stratified screening program according to the risk of gastric cancer
  • Coenzyme Q10 (ubiquinone) and its physical value in elder population
  • Advantage of cold polypectomy for rectal polyp compared to standard polypectomy
Division of Medical Research Management, Department of Biomedical Science

The division was formed out of a deep commitment to improving patients’ lives through the synergy of real-world clinical and healthcare data and advanced information technology. We has built a highly secured multinational data network from the rich clinical, operational and financial data of clinical and healthcare field.
Our clinical data warehouse and analytics improves efficiency and effectiveness in operations, treatment, and patient engagement. We provides aggregated and validated big data for upstream and downstream insights into medical and healthcare questions. It accelerates medical research into such areas as treatment outcomes, real-world evidence, and health economics.

Division of Companion Diagnostics, Department of Pathology and Microbiology

The aim of the division is to isolate the novel biomarkers of diseases utilizing as companion diagnosis. The division was established on October 1, 2013 supported by a grant from the Health Sciences Research Institute, Inc., Yokohama, Japan. It continues by donation from Dr. Tetsumasa Miya of the company from October 1, 2016. We will try to construct a companion diagnosis to fuse the clinical laboratory with clinical genetics, and offer these results for the society.

  • To isolate the novel biomarkers of diseases utilizing as companion diagnosis
  • Prediction of drug effects and adverse effects using clinical data mining
  • Search for genetic markers of diabetes vascular complications
  • To isolate novel susceptibility markers in neurological disorders
  • Search for a causal gene in psychosis
  • Disease susceptibility gene analyses in macular diseases
  • Research for development and differentiation of brain tumor stem cells
  • Basic research for multidrug therapy in patients with glioma
  • To analyze the genomic background of gastrointestinal diseases
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