Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes.

Tomofuji Y, Suzuki K, Kishikawa T, Shojima N, Hosoe J, Inagaki K, Matsubayashi S, Ishihara H, Watada H, Ishigaki Y; BioBank Japan Project; Inohara H, Murakami Y, Matsuda K, Okada Y, Yamauchi T, Kadowaki T.

Commun Med (Lond), 3, 5.

Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes.

Saigusa T, Watanabe K, Hada Y, Ishii K, Kameda W, Susa S, Ishizawa K, Ishihara H.

BMC Cardiovasc Disord, 22, 365.

Fibrosis-4 index is closely associated with arterial damage and future risk of coronary heart disease in type 2 diabetes.

Watanabe K, Takakubo N, Saigusa T, Nagasawa A, Yamana M, Ojima M, Kameda W, Susa S, Ishizawa K, Ishihara H.

Int J Hypertens. in press.

Glucagon responses to glucose challenge in patients with idiopathic postprandial syndrome.

Kosuda M, Watanabe K, Koike M, Morikawa A, Saito H, Kohno G, Ishihara H.

J Nippon Med.Sch,89, 102-107.

Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases.

Yamamotoya T, Hasei S, Akasaka Y, Ohata Y, Nakatsu Y, Kanna M, Fujishiro M, Sakoda H, Ono H, Kushiyama A, Misawa H, Asano T.

Sci Rep.12, 1966

Impact of female sex on the susceptibility to hypernatremia among older community-dwelling individuals in Japan.

Tanaka S, Fujishiro M, Imatake K, Suzuki Y, Ishihara H, Tani S.

Int J Gen Med, 15, 777-785.

Aortic arch calcification with pericardial fat mass detected on single chest X-ray image is closely associated with the predictive variables of future cardiovascular diease.

Watanabe K, Hada Y, Ishii K, Nagaoka K, Takase K, Kameda W, Susa S, Saigusa T, Egashira F, Ishihara H, Ishizawa K.

Heart Vessels,37, 654-664.

高齢2型糖尿病患者でのオステオカルシンの動脈硬化信連および血管石灰化に与える影響に関する研究.

渡邉健太郎.

日本老年医学会誌, 58, 315-317.

Using recombinase-mediated cassette exchange to engineer MIN6 insulin-secreting cells based on a newly identified safe harbor locus.

Furukawa A, Tanaka A, Yamaguchi S, Kosuda M, Yamana M, Nagasawa A, Kohno G, Ishihara H.

J Diabetes Investig, 12, 2129-2140.

Effects of GLP-1RA and SGLT2i, alone or in combination, on mouse models of type 2 diabetes representing different disease stages.

Koike M, Saito H, Kohno G, Takubo M, Watanabe K, Ishihara H.

Int J Mol Sci, 22, 11463.

Impact of plasma xanthine oxidoreductase activity on the mechanisms of distal symmetric polyneuropathy development in patients with type 2 diabetes.

Fujishiro M, Ishihara H, Ogawa K, Murase T, Nakamura T, Watanabe K, Sakoda H, Ono H, Yamamotoya T, Nakatsu Y, Asano T, Kushiyama A.

Biomedicines. 9, 1052.

Tuberculosis relapse in the epididymis after the completion of nine months of anti-tuberculosis chemotherapy in a patient with poorly controlled diabetes mellitus.

Ichikawa C, Tanaka S, Takubo M, Kushimoto M, Ikeda J, Ogawa K, Tsujino I, Suzuki Y, Abe M, Ishihara H, Fujishiro M.

Ther Clin Risk Manag. 17, 463-470.

Pathological role of Pin1 in the development of DSS-induced colitis.

Matsunaga Y, Hasei S, Yamamotoya T, Honda H, Kushiyama A, Sakoda H, Fujishiro M, Ono H, Ito H, Okabe T, Asano T, Nakatsu Y.

Cells. 10, 1230.

Carnosic acid and carnosol activate AMPK, suppress expressions of gluconeogenic and lipogenic genes, and inhibit proliferation of HepG2 cells.

Hasei S, Yamamotoya T, Nakatsu Y, Ohata Y, Itoga S, Nonaka Y, Matsunaga Y, Sakoda H, Fujishiro M, Kushiyama A, Asano T.

Int J Mol Sci. 22, 4040.

Clinical study of cerebral ischemia in moyamoya disease from the view of development of the anterior choroidal artery.

Ogawa K, Akimoto T, Hara M, Fujishiro M, Nakajima H.

J Stroke Cerebrovasc Dis. 30, 106078.

A case of cutis verticis gyrata-mental retardation syndrome accompanied by various neurological abnormalities.

Ogawa K, Akimoto T, Hara M, Fujishiro M, Nakajima H.

Neurol Clin Neurosci. 9, 487-489.

Clinical study of seven patients with infarction in the territory of the anterior choroidal artery.

Ogawa K, Akimoto T, Hara M, Fujishiro M, Suzuki Y, Soma M, Nakajima H.

Nichidai Igaku Zasshi. 80, 303-310.

Seasonal variation in hydration status among community-dwelling elderly in Japan.

Tanaka S, Fujishiro M, Watanabe K, Imatake K, Suzuki Y, Abe M, Ishihara H, Tani S

Geriatrics & Gerontology International. 20, 904-910.

A case of prosopometamorphopsia caused by infarction of the splenium of the corpus callosum and major forceps.

Ogawa K, Abe M, Akimoto T, Takahashi K, Hara M, Morita A, Kamei S, Nakajima H, Fujishiro M, Soma M, Shikata E, Futamura A, Kawamura M

Neurocase. 26, 264-269.

Effect of adult weight gain on non-alcoholic fatty liver disease and its association with anthropometric parameters in the lean Japanese population.

Tanaka S, Fujishiro M, Watanabe K, Imatake K, Suzuki Y, Abe M, Ishihara H, Tani S

Diagnostics(Basel). 10, 863.

Comparison of tofogliflozin versus glimepiride as the third oral agent added to metformin plus a dipeptidyl peptidase-4 inhibitor in Japanese patients with type 2 diabetes: A randomized, 24-week, open-label, controlled trial (STOP-OB).

Kitazawa T, Seino H, Ohashi H, Inazawa T, Inoue M, Ai M, Fujishiro M, Kuroda H, Yamada M Anai M, Ishihara H

Diabetes Obes Metab. 22, 1659-1663.

A rare case of fulminany type 1 deabetes mellitus accompanied and myocarditis.

Egashira F, Kawashima M, Morikawa A, Kosuda M, Ishihara H, Watanabe K

BMC Endcrine Diasorers. 20, 127.

Inverse correlation between grip strength and serum phosphorus: A retrospective observational study in Japanese elderly with poorly controlled type 2 diabetes.

Tanaka S, Takubo M, Kohno G, Kushimoto M, Ikeda J, Ogawa K, Suzuki Y, Abe M, Ishihara H, Fujishiro M

Geriatrics (Basel). 5, 33.

Hyponatremia associated with prophylactic low-dose trimethoprim during systemic corticosteroid therapy for AQP4-positive optic neuritis in a diabetic patient.

Takubo M, Tanaka S, Kushimoto M, Ikeda J, Ogawa K, Suzuki Y, Abe M, Ishihara H, Fujishiro M

Antibiotics (Basel). 9, 201.

A Single episode of hypoglycemia as a possible early warning sign of adrenal insufficiency.

Tanaka S, Abe M, Kohno G, Kushimoto M, Ikeda J, Ogawa K, Suzuki Y, Ishihara H,
Fujishiro M

Ther Clin Risk Manag. 16, 147-153

Isolated ACTH deficiency during single-agent pembrolizumab for squamous cell lung carcinoma.

Tanaka S, Kushimoto M, Nishizawa T, Takubo M, Mitsuke K, Ikeda J, Fujishiro M,
Ogawa K, Tsujino I, Suzuki Y, Abe M

Clin Diabetes Endocrinol. 6, 1

Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A.

Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Takaeko Y, Yamaji T, Harada T, Han Y, Aibara Y, Mohamad Yusoff F, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T Ito H, Ikeda H, Yamashina A, Higashi Y

Hypertens Res. 43, 781-790

Diagnostic criteria of flow-mediated vasodilation for normal endothelial function and nitroglycerin-induced vasodilation for normal vascular smooth muscle function of the brachial artery.

Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Mohamad Yusoff F, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y

J Am Heart Assoc. 9, e013915.

Acute esophageal necrosis after cellulitis in an obese patient with diabetes mellitus.

Tanaka S, Fujishiro M, Ichijima R, Kohno G, Abe M, Ishihara H

J Diabetes Investig. 11, 250-252

Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells.

Nakatsu Y, Yamamotoya T, Ueda K, Ono H, Inoue MK, Matsunaga Y, Kushiyama A,
Sakoda H, Fujishiro M, Matsubara A, Asano T

Cancer Lett. 470, 106-114.

Development of Pin1 inhibitors and their potential as therapeutic agents.

Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK,
Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T

Curr Med Chem. 27, 3314-3329.

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins.

Inoue M, Nakatsu Y, Yamamotoya T, Hasei S, Kanamoto M, Naitou M, Matsunaga Y,
Sakoda H, Fujishiro M, Ono H, Kushiyama A, Asano T

Cells. 8, 1545.

Clinical study of thirteen patients with spinal cord infarction.

Ogawa K, Akimoto T, Hara M, Morita A, Fujishiro M, Suzuki Y, Soma M, Kamei S,
Nakajima H

J Stroke Cerebrovasc Dis. 28, 104418.

Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice.

Inoue M, Matsunaga Y, Nakatsu Y, Yamamotoya T, Ueda K, Kushiyama A, Sakoda H,
Fujishiro M, Ono H, Iwashita M, Sano T, Nishimura F, Morii K, Sasaki K, Masaki T,
Asano T

Diabetol Metab Syndr. 11, 57

Two adult siblings with myotonic dystrophy type 1 with different phenotypes presenting with chronic respiratory insufficiency and sleep apnea syndrome.

Kohno G, Ogawa K, Kushimoto M, Tanaka S, Ikeda J, Nishizawa T, Mitsuke K,
Nakayama T, Suzuki Y, Ishihara H, Fujishiro M

Front Neurol. 10, 681

Prolyl isomerase Pin1 suppresses thermogenic programs in adipocytes by promoting degradation of transcriptional co-activator PRDM16.

Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue M, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi S, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T

Cell Reports. 26, 3221-3230

Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation.

Ueda K, Nakatsu Y, Yamamotoya T, Ono H, Inoue Y, Inoue M, Mizuno Y, Matsunaga Y, Kushiyama A, Sakoda H, Fujishiro M, Takahashi S, Matsubara A, Asano T

Oncotarget. 10, 1637-1648.

Retention of aberrant cortisol secretion in a patient with bilateral macronodular adrenal hyperplasia after unilateral adrenalectomy.

Tanaka S, Fujishiro M, Nakamura Y, Hatanaka Y, Abe M

Ther Clin Risk Manag. 15, 337-342.

Target of triglycerides as residual risk for cardiovascular events in patients with coronary artery disease-post hoc analysis of the FMD-J Study A.

Kajikawa M, Maruhashi T, Kishimoto S, Matsui S, Hashimoto H, Takaeko Y, Yusoff FM, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y

Circ J. 83, 1064-1071

Xanthine oxidase inhibitor febuxostat exerts an anti-inflammatory action and protects against diabetic nephropathy development in KK-Ay obese diabetic mice.

Mizuno Y, Yamamotoya T, Nakatsu Y, Ueda K, Matsunaga Y, Inoue M, Sakoda H, Fujishiro M, Ono H, Kikuchi T, Takahashi M, Morii K, Sasaki K, Masaki T, Asano T, Kushiyama A

Int J Mol Sci. 20, 4680

The xanthine oxidase inhibitor febuxostat suppresses the progression of IgA nephropathy possibly via its anti-inflammatory and anti-fibrotic effects in the gddY mouse model.

Inoue MK, Yamamotoya T, Nakatsu Y, Ueda K, Inoue Y,
Matsunaga Y, Sakoda H, Fujishiro M, Ono H, Mori K, Sasaki K, Masaki T, Suzuki Y, Asano T, Kushiyama A

Int J Mol Sci. 19, 3967

Elsberg syndrome related to varicella zoster virus infection with painless skin lesions in an elderly woman with poorly controlled type 2 diabetes mellitus.

Saito H, Ebashi M, Kushimoto M, Ikeda J, Egashira F, Yamaguchi S, Watanabe K, Ogawa K, Suzuki Y, Ishihara H, Fujishiro M

Ther Clin Risk Manag. 14, 1951-1954.

Roles of gut-derived secretory factors in the pathogenesis of non-alcoholic fatty liver disease and their possible clinical applications.

Okubo H, Kushiyama A, Nakatsu Y, Yamamotoya T, Matsunaga Y, Fujishiro M, Sakoda H, Ohno H, Yoneda M, Asano T

Int J Mol Sci. 19, 3064

Protective effect of sex homone-binding globulin against metabolic syndrome: in vitro evidence showing anti-inflammatory and lipolytic effects on adipocytes and macrophages.

Yamazaki H, Kushiyama A, Sakoda H, Fujishiro M, Yamamotoya T, Nakatsu Y, Kikuchi T, Kaneko S, Tanaka H, Asano T

Mediators Inflamm. 2018, 3062319.

Rationale and design of the STOP-OB study for evaluating the effects of tofogliflozin and glimepiride on fat deposition in type 2 diabetes patinets treated with metformin/DPP-4 inhibitor dual therapy.

Ishihara H, Anai M, Seino H, Kitazawa T, Ohashi H, Ai M, Inoue M, Fujishiro M, Inazawa T, Kuroda H, Yamada M

Diabetes Ther. 9, 2117-2125.

Gut microbiota as a therapeutic target for metabolic disorders.

Okubo H, Nakatsu Y, Kushiyama A, Yamamotoya T, Matsunaga Y,
Inoue MK, Fujishiro M, Sakoda H, Ohno H, Yoneda M, Ono H, Asano T

Curr Med Chem. 25, 984-1001.

Endothelial dysfunction, increased arterial stiffness, and cardiovascular risk prediction in patients with coronary artery disease: FMD-J (Flow-Mediated Dilation Japan) Study A.

Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Yusoff FM, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H Yamashina A, Higashi Y

J Am Heart Assoc. 7, e008588.

Brachial artery diameter as a maker for cardiovascular risk assessment: FMD-J study.

Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Yusoff FM, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H Yamashina A, Higashi Y

Atherosclerosis. 268, 92-98.

Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.

Yamamotoya T, Nakatsu Y, Kushiyama A, Matsunaga Y, Ueda K, Inoue Y, Inoue M, Sakoda H, Fujishiro M, Ono H, Kiyonari H, Ishihara H, Asano T

Sci Rep. 7, 13026.

Gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus.

Fujishiro M, Kushiyama A, Yamazaki H, Kaneko S, Koketsu Y, Yamamotoya T, Kikuchi T, Sakoda H, Suzuki R, Kadowaki T

World J Gastroenterol. 23, 6694-6704.

Severe hypertriglyceridemia possibly masked acute pancreatitis and led to a difficult diagnosis in an obese patient with ketoacidosis-onset type 2 diabetes.

Fujishiro M, Horita A, Nakagawara H, Mawatari T, Kishigami Y,
Tominaga Y, Moriyama M, Ishihara H

Intern Med. 56, 2611-2616.

The SGLT2 Inhibitor luseogliflozin rapidly normalizes aortic mRNA levels of inflammation-related but not lipid-metabolism-related genes and suppresses atherosclerosis in diabetic ApoE KO mice.

Nakatsu Y, Kokubo H, Bumdelger B, Yoshizumi M, Yamamotoya T, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Fujishiro M, Kushiyama A, Ono H, Sakoda H, Asano T.

Int J Mol Sci. 18, 1704.

The prolyl isomerase Pin1 increases β cell proliferation and enhances insulin secretion.

Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H,
Ishihara H, Asano T

J Biol Chem. 292, 11886-11895.

Reduced SHARPIN and LUBAC formation may contribute to CCl₄- or acetaminophen-induced liver cirrhosis in mice.

Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H

Int J Mol Sci. 18, 326.

A case of insulin allergy successfully managed using multihexamer-forming insulin degludec combined with liraglutide.

Fujishiro M, Izumida Y, Takemiya S, Kuwano Y, Takamoto I, Suzuki R, Yamauchi T, Ueki K, Kadowaki T.

Diabet Med. 33, e26-e29.

Controversy regarding gastric cancer and diabetes.

Fujishiro M, Ishihara H

J Gastroenterol. 51, 80-81.

Octreotide for hypoglycemia caused by sulfonylurea and DPP-4 inhibitor.

Yamaguchi S, Ikejima M, Furukawa A, Abe M, Nakazaki M,
Ishihara H

Diabetes Res Clin Pract. 109, e8-e10.

Addition of sitagliptin or metformin to insulin monotherapy improves blood glucose control via different effects on insulin and glucagon secretion in hyperglycemic Japanese patients with type 2 diabetes.

Otsuka Y,Yamaguchi S, Furukawa A, Kosuda M, Nakazaki M,
Ishihara H

Endocr J. 62, 133-143.

Usefulness of the Pain Vision PS-2100, a device for the quantitative analysis of perception and pain sensation, for evaluating early stage dabetic polyneuropathy

Okamoto M, Egashira F, Taki M, Nakajima H, Ogihara N, Takamura H,
Yoshikawa S, Hayashi Y, Ishihara H

J Japan Diab Soc. 56, 343-349.