Last updated: 2021-10-20


  1. Ohni S, Yamaguchi H, Hirotani Y, Nakanishi Y, Midorikawa Y, Sugitani M, Naruse H, Nakayama T, Makishima M, Esumi M. Direct molecular evidence for both multicentric and monoclonal carcinogenesis followed by transdifferentiation from hepatocellular carcinoma to cholangiocarcinoma in a case with metachronous liver cancer. Oncol Lett, in press
  2. Ishizawa Μ, Hirayu Α, Makishima Μ. Zinc inhibits cadherin 1 expression induced by 1α,25-dihydroxyvitamin D3 in colon cancer cells. Anticancer Red, in press
  3. Wang X, Sato F, Tanimoto K, Makishima M, Bhawal UK. The potential roles of Dec1 and Dec2 in periodontal inflammation. Int J Mol Sci 22: 10349, 2021
  4. Kobayashi H, Nakai T, Nakanishi Y, Esumi M, Masada. Phylogenetic analysis of combined lobular and ductal carcinoma of the breast. Mol Med Rep 24: 718, 2021
  5. Ishikiriyama T, Nakashima H, Endo-Umeda K, Nakashima M, Ito S, Kinoshita M, Ikarashi M, Makishima M, Seki S. Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation.PLoS ONE 16: e0254886, 2021
  6. Morimoto J, Miyamoto K, Ichikawa Y, Uchiyama M, Makishima M, Hashimoto Y, Ishikawa M. Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog. Sci Rep 11: 12697, 2021
  7. Oka S, Li X, Zhang F, Tewari N, Wang C, Kim I, Zhong L, Hamada N, Oi Y, Makishima M, Liu Y, Bhawal UK. Inhibition of Dec1 provides biological insights into periodontal pyroptosis. All Life 14: 300-307, 2021
  8. Oka S, Li X, Zhang F, Tewari N, Kim I, Chen C, Zhong L, Hamada N, Oi Y, Makishima M, Liu Y, Bhawal UK. Loss of Dec1 prevents autophagy in inflamed periodontal ligament fibroblast. Mol Biol Rep 48: 1423-1431, 2021
  9. Oka S, Li X, Sato F, Zhang F, Tewari N, Kim I, Zhong L, Hamada N, Makishima M, Liu Y, Bhawal UK. A deficiency of Dec2 triggers periodontal inflammation and pyroptosis. J Periodontal Res 56: 492-500, 2021
  10. Oka S, Li X, Zhang F, Tewari N, Ma R, Zhong L, Makishima M, Liu Y, Bhawal UK. MicroRNA-21 facilitates osteoblast activity. Biochem Biophys Rep 25: 100894, 2021
  11. Yukawa-Takamatsu K, Wang Y, Watanabe M, Takamura Y, Fujihara M, Nakamura-Nakayama M, Yamada S, Kikuzawa S, Makishima M, Kawasaki M, Ito S, Nakano S, Kakuta H. Convenient retinoid X receptor binding assay based on fluorescence change of the antagonist NEt-C343. J Med Chem 64: 861-870, 2021
  12. Watanabe M, Fujihara M, Motoyama T, Kawasaki M, Yamada S, Takamura Y, Ito S, Makishima M, Nakano S, Kakuta H. Discovery of a “gatekeeper” antagonist that blocks entry pathway to retinoid X receptors without allosteric ligand inhibition in permissive RXR heterodimers. J Med Chem 64: 430-439, 2021
  13. Ichikawa Y, Hiramatsu M, Mita Y, Makishima M, Matsumoto Y, Masumoto Y, Muranaka A, Uchiyama M, Hashimoto Y, Ishikawa M. meta-Non-flat substituents: A novel molecular design to improving aqueous solubility in small molecule drug discovery. Org Biomol Chem 19: 446-456, 2021
  14. Oka S, Li X, Zhang F, Tewari N, Zhong L, Makishima M, Liu Y, Bhawal UK. Dec2 attenuates autophagy in inflamed periodontal tissues. Immun Inflamm Dis 9: 265-273, 2021
  15. Terui R, Yanase Y, Yokoo H, Suhara Y, Makishima M, Demizu Y, Misawa T. Development of novel selective TGR5 ligands based on 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphtaklene skeleton. ChemMedChem 16: 458-462, 2021