publication of Division of Biochemistry, Nihon University School of Medicine


Last updated: 2018-09-19


  1. Wada T, Ichihashi Y, Suzuki E, Kosuge Y, Ishige K, Uchiyama T, Makishima M, Nakao R, Oishi K, Shimba S. Deletion of Bmal1 prevents diet-induced ectopic fat accumulation by controlling oxidative capacity in the skeletal muscle. Int J Mol Sci 19: 2813, 2018
  2. Nishiyama Y, Fujii S, Makishima M, Hashimoto Y, Ishikawa M. Efficient lead finding, activity enhancement and preliminary selectivity control of nuclear receptor ligands bearing a phenanthridinone skeleton.Int J Mol Sci 19: 2090, 2018
  3. Otero R, Ishizawa M, Numoto N, Ikura T, Ito N, Tokiwa H, Mourino A, Makishima M, Yamada S. 25S-Adamantyl-23-yne-26,27-dinor-1α,25-dihydroxyvitamin D3: synthesis, tissue selective biological activities and X-ray crystal structural analysis of its vitamin D receptor complex. J Med Chem 61: 6658-6673, 2018
  4. Ishizawa M, Akagi D, Makishima M. Lithocholic acid is a vitamin D receptor ligand that acts preferentially in the ileum. Int J Mol Sci 19: 1975, 2018
  5. Kainuma M, Takada I, Makishima M, Sano K. Farnesoid X receptor activation enhances transforming growth factor β-induced epithelial-mesenchymal transition in hepatocellular carcinoma cells. Int J Mol Sci 19: 1898, 2018
  6. Nishiyama Y, Mori S, Makishima M, Fujii S, Kagechika H, Hashimoto Y, Ishikawa M. Novel non-steroidal progesterone receptor (PR) antagonists with a phenanthridinone skeleton. ACS Med Chem Lett 9: 641-645, 2018
  7. Endo-Umeda K, Nakashima H, Komine-Aizawa S, Umeda N, Seki S, Makishima M. Liver X receptors regulate hepatic F4/80+CD11b+ Kupffer cells/macrophages and innate immune responses in mice. Sci Rep 18: 9281, 2018
  8. Shioi R, Toyota Y, Noguchi-Yachide T, Ishikawa M, Yamaguchi T, Makishima M, Hashimoto Y, Ohgane K. Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands. Heterocycles, in press
  9. Nakagawa M, Uno S, Iriyama N, Matsunawa M, Makishima M, Takeuchi J, Tsuboi I, Hatta Y, Takei M. Combined treatment with benzo[a]pyrene and 1α,25-dihydroxyvitamin D3 induces expression of plasminogen activator inhibitor 1 in monocyte/macrophage-derived cells. Toxicol Appl Pharmacol 345: 48-56, 2018
  10. Takada I, Tsuchiya M, Yanaka K, Hidano S, Takahashi S, Kobayashi T, Ogawa H, Nakagawa S, Makishima M. Ess2 bridges transcriptional regulators and spliceosomal complexes via distinct interacting domains. Biochem Biophys Res Commun 497: 597-604, 2018
  11. Uno S, Tanaka T, Ashiba H, Fujimaki M, Tanaka M, Hatta Y, Takei M, Awazu K, Makishima M. Sensitive typing of reverse ABO blood groups with a waveguide-mode sensor. J Biosci Bioeng 126: 131-137, 2018
  12. Endo-Umeda K, Nakashima H, Umeda N, Seki S, Makishima M. Dysregulation of Kupffer cells/ macrophages and natural killer T cells in steatohepatitis in LXRα knockout male mice. Endocrinology 159: 1419-1432, 2018
  13. Uno S, Nebert DW, Makishima M. Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. Food Chem Toxicol 113: 73-82, 2018
  14. Nomura S, Endo-Umeda K, Fujii S, Makishima M, Hashimoto Y, Ishikawa M. Structural development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists with improved aqueous solubility. Bioorg Med Chem Lett 28: 796-801, 2018
  15. Ishibashi M, Yamaguchi H, Hirotani Y, Sakurada A, Endo T, Sugitani M, Takayama T, Makishima M, Esumi M. Contradictory intrahepatic immune responses activated in high-load hepatitis C virus livers compared with low-load livers. Arch Virol 163: 855-865, 2018
  16. Chuma M, Makishima M, Imai T, Tochikura N, Suzuki S, Kuwana T, Sawada N, Komatsu T, Sakaue T, Kikuchi N, Yoshida Y, Kinoshita K. Relationship between initial vancomycin trough levels and early-onset vancomycin-associated nephrotoxicity in critically ill patients. Ther Drug Monit 40: 109-114, 2018
  17. Neelankal John A, Iqbal Z, Colley S, Morahan G, Makishima M, Jiang FX. Vitamin D receptor-targeted treatment to prevent pathological dedifferentiation of pancreatic β cells under hyperglycaemic stress. Diabetes Metab 44: 269-280, 2018
  18. 槇島誠.核内受容体クロストークと脂質胆汁酸代謝の関連.肝胆膵 77: 7-14, 2018
  19. 槇島誠.ビタミンDの生理作用と作用メカニズム.食と医療 5: 20-27, 2018