publication of biochemistry (cyberduck)


Last updated: 2017-12-13


  1. Nomura S, Endo-Umeda K, Fujii S, Makishima M, Hashimoto Y, Ishikawa M. Structural development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists with improved aqueous solubility. Bioorg Med Chem Lett, in press
  2. Ishibashi M, Yamaguchi H, Hirotani Y, Sakurada A, Endo T, Sugitani M, Takayama T, Makishima M, Esumi M. Contradictory intrahepatic immune responses activated in high-load hepatitis C virus livers compared with low-load livers. Arch Virol, in press
  3. Nishina A, Itagaki M, Sato D, Kimura H, Hirai Y, Phay N, Makishima M. Rosiglitazone-like effect of vitexilactone, a constituent from Vitex trifolia L. in 3T3-L1 preadipocytes. Molecules 22: 2030, 2017
  4. Chuma M, Makishima M, Imai T, Tochikura N, Suzuki S, Kuwana T, Sawada N, Komatsu T, Sakaue T, Kikuchi N, Yoshida Y, Kinoshita K. Relationship between initial vancomycin trough levels and early-onset vancomycin-associated nephrotoxicity in critically ill patients. Ther Drug Monit, in press
  5. Sakane R, Kimura K, Hirota Y, Ishizawa M, Takagi Y, Wada A, Kuwahara S, Makishima M, Suhara Y. Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities. Bioorg Med Chem Lett 27: 4881-4884, 2017
  6. Neelankal John A, Iqbal Z, Colley S, Morahan G, Makishima M, Jiang FX. Vitamin D receptor-targeted treatment to prevent pathological dedifferentiation of pancreatic β cells under hyperglycaemic stress. Diabetes Metab, in press
  7. Endo-Umeda K, Aoyama A, Shimizu M, Ishikawa M, Hashimoto Y, Yamada S, Makishima M. 1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators. J Steroid Biochem Mol Biol 172: 136-148, 2017
  8. Arichi N, Fujiwara S, Ishizawa M, Makishima M, Hua HD, Yamada K, Yamaoka Y, Takasu K. Synthesis and biological evaluation of steroidal derivatives bearing a small ring as vitamin D receptor agonists. Bioorg Med Chem Lett 27: 3408-3411-2017
  9. Ishizawa M, Akagi D, Yamamoto J, Makishima M. 1α,25-Dihydroxyvitamin D3 enhances TRPV6 transcription through p38 MAPK activation and GADD45 expression. J Steroid Biochem Mol Biol 172: 55-61, 2017
  10. Tamura M, Ishizawa M, Isojima T, Ozen S, Oka A, Makishima M, Kitanaka S. Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia. Sci Rep 7: 5102, 2017
  11. Shioi R, Okazaki S, Noguchi-Yachide T, Ishikawa M, Makishima M, Hashimoto Y, Yamaguchi T. Switching subtype-selectivity: fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists. Bioorg Med Chem Lett 27: 3131-3134, 2017
  12. Toyota Y, Nomura S, Makishima M, Hashimoto Y, Ishikawa M. Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression. Bioorg Med Chem Lett 27: 2776-2780, 2017
  13. Shimizu T, Tanaka T, Uno S, Ashiba H, Fujimaki M, Tanaka M, Awazu K, Makishima M. Detection of antibodies against hepatitis B virus surface antigen and hepatitis C virus core antigen in plasma with a waveguide-mode sensor. J Biosci Bioeng 123: 760-764, 2017
  14. Kuroda C, Ohki Y, Ashiba H, Fujimaki M, Awazu K, Makishima M. Design of a sedimentation hole in a microfluidic channel to remove blood cells from diluted whole blood. Jpn J Appl Phys 56: 037201, 2017
  15. Misawa T, Fujisato T, Kanda Y, Ohoka N, Shoda T, Yorioka M, Makishima M, Sekino Y, Naito M, Demizu Y, Kurihara M. Design and synthesis of novel selective estrogen receptor degradation inducers based on diphenylheptane skeleton. MedChemComm 8: 239-246, 2017
  16. Takada I, Makishima M. Control of inflammatory bowel disease and colorectal cancer by synthetic vitamin D receptor ligands. Curr Med Chem 24: 868-875, 2017
  17. 槇島誠.ビタミンD受容体と核内受容体.Clinical Calcium 27: 1533-1541, 2017
  18. 三澤隆史、出水庸介、谷内出友美、大岡伸通、野尻久雄、橘高敦史、槇島誠、内藤幹彦、栗原正明.長鎖アルキル基を有するノンセコステロイド型VDRリガンドの創製.ビタミン 91: 113-120, 2017