Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine

Kosaku Kinoshita

Kosaku Kinoshita, M.D., PhD.
Professor, Division of Emergency and Critical Care Medicine,
Department of Acute Medicine, Nihon University School of Medicine

30-1 Oyaguchi Kamimachi Itabashi-ku, Tokyo
173-8610, Japan
TEL: +81-3-3972-8111
Ext: 2828, 8361
FAX: +81-3-5964-8037
E-mail: kinoshita.kosaku@nihon-u.ac.jp

Distinct characteristics of our program and critical care unit

As our national population ages, we are seeing a yearly increase in the number of people requiring emergency medical care. Conversely, the number of child deaths due to accidents in Japan is high even among advanced nations, exposing the urgent need to build regional wide-area emergency care systems. In addition to being designated (by the Ministry of Health, Labour and Welfare) as an advanced treatment hospital in a secondary medical area serving 1.8 million residents, Nihon University Itabashi Hospital also serves as a Base Hospital for Disasters, a Pediatric Emergency and Critical Care Center, a Maternal Emergency and Critical Care and General Perinatal Emergency Medical Care Center, a Priority Hospital for Emergency Aortic Disease, and is a participating facility in the CCU Network and the Tokyo Burn Unit Association. Annually, over 2,200 seriously and critically sick and wounded patients are transported to our Critical Care Unit who require a wide variety of treatment including surgery for, among other symptoms, external injuries, burns, acute abdomen, acute coronary syndrome, poisoning, cardiopulmonary arrest, and other internal medical diseases. We are especially focusing on radical medicine that applies acute care for external injuries, acute care and cerebral protection therapy for central nervous system diseases, catheter therapy for acute coronary syndrome, intensive care for severe sepsis, and extracorporeal circulation and cerebral hypothermia therapy for cardiopulmonary arrest.
We conduct research on emergency and intensive care for pre-hospital and initial therapy and in the field of intensive care medicine. For the latter field, our research even covers: pathophysiological analysis and control of severe stress that occurs in severely traumatized or septic patients; comprehensive search for biomarkers associated with clinical outcomes of sepsis, cerebral infarction, and post cardiac arrest syndrome; establishing a nutrition therapy for critically ill patients; early brain function assessment method for post cardiac arrest syndrome patients; development of non-invasive cerebral protection devices (pulmonary cooling devices); and neurological intensive care and neurological monitoring.


  1. Kinoshita K, Kushi H, Sakurai A, Utagawa A, Saito T, Moriya M, Hayashi H: Risk factors for intraoperative hypotension in traumatic intracranial hematoma. Resuscitation.2004; 60: 151-55.
  2. Kinoshita K, Furukawa M, Ebihara T, Sakurai A, Noda A, Kitahata Y, Utagawa A, Tanjoh K: Acceleration of chemokine production from endothelial cells in response to lipopolysaccharide in hyperglycemic condition. Acta Neurochir Suppl. 2006; 96: 419-21.
  3. Kinoshita K, Yamaguchi J, Sakurai A, Ebihara T, Furukawa M, Tanjoh K: Inhibition of lipopolysaccharide stimulated interleukin-1beta production after subarachnoid hemorrhage. Neurol Res. 2007; 29: 47-52.
  4. Kinoshita K, Tanjoh K, Noda A, Sakurai A, Yamaguchi J, Azuhata T, Utagawa, A, Moriya T: Interleukin-8 production from human umbilical vein endothelial cells during brief hyperglycemia: The effect of tumor necrotic factor alpha. J Surg Res.2008; 144 (1):127-31.
  5. Kinoshita K, Moriya T, Utagawa A, Sakurai A, Mukoyama T, Furukawa M, Yamaguchi J, Tanjoh K. Change in Brain Glucose After Enteral Nutrition in Subarachnoid Hemorrhage. J Surg Res. 2010; 162 (2):221-24.
  6. Kinoshita K, Sakurai K, Yamaguchi J, Furukawa M, Tanjoh K. Delayed augmentation effect of cytokine production after hyperthermia stimuli. Molecular Biology.2014; 48: 371-76.
  7. Kinoshita K: Possibility of predicting neurological outcome using regional cerebral oxygen saturation (rSO2) after cardiac arrest. Resuscitation. 2014; 85(9): e133.
  8. Kinoshita K, Azuhata T, Kawano D, Kawahara Y: Relationships between pre-hospital characteristics and outcome in victims of foreign body airway obstruction during meals. Resuscitation 2014, 88c: 63-67.
  9. Kinoshita K, Sakurai A, Ihara S. The pitfalls of bedside regional cerebral oxygen saturation in the early stage of post cardiac arrest. Scand J Trauma Resusc Emerg Med. Nov 11; 23(1):95. 2015.
  10. Kinoshita K, Kuwana T, Hori S. Transient Heterotopic Calcification and Unexpected Hypercalcemia after Treatment of Septic Shock. Intern Med. 2016;55(9):1207-11.
  11. Kinoshita K: Traumatic brain injury: Pathophysiology for neurocritical care. J Intensive Care 4:29, 2016