日大医学雑誌

Increased Prevalence of High Risk HPV in Patients with
Sexually Transmitted Diseases

原著

著者

Chiho KOGANEI-MURABAYASHI1), Satoshi HAYAKAWA1, 2), Kazufumi SHIMIZU2),
Tatsuo YAMAMOTO1), Aleemuzzaman SHEIKH3) and Norimichi NEMOTO3)
1)Department of Obstetrics and Gynaecology, Nihon University School of Medicine
2)Department of Infectious Disease Control, Nihon University Advanced Medical Research Center
3)Department of Pathology, Nihon University School of Medicine

要旨

The acquisition of human papillomavirus (HPV), the most important etiological agent of cervical cancer, doesnot cause clinical complaints. Although HPV spreads together with other pathogens causing sexually transmitteddiseases (STD) with complaints forcing the patient to seek medical advices for STD, STD have not yet beenevaluated as a predictors of cervical cancer themselves. The present study aimed to determine the relationshipbetween STD and HPV in order to evaluate the possible role of STD as a risk factor of cervical cancer. Threegroups of patients were studied: (i) 56 women with STD (ii) 51 control women (iii) 25 patients with cervicalneoplasms. The presence of HPV and other STD in cervical smears was detected with liquid phase hybridizationand polymerase-chain reaction. HPV prevalence was 30% in patients with STD, and 12% in the group of womenwithout pelvic inflammatory diseases (PID) (p < 0.05), 76% in the patients with cervical neoplasms (p < 0.001). Onthe contrary to our expectation, morphological abnormalities with PAP smear class III or more were detected only7.5% of the STD patients with HPV infection. Our results suggests that patients suffering from STD apparentlyhave high risk of cervical cancer but scarcely detectable with morphological methods. Thus patients with STDrequire managements with both virological and cytological procedures.

keyword

HPV, STD, carcinoma of uterine cervix, CIN