総説

著者

早川　智
日本大学医学部先端医学講座感染制御科学部門

要旨

Impaired cellular immune function during pregnancy often deteriorates to viral infections. Some viruses such as rubellavirus, herpes simplex virus (HSV), human parvovirus (B19), and cytomegalovirus (CMV) injure fetuses directly; othersaffect pregnancy outcome through systemic inflammatory responses and subsequent placental dysfunction and/or uterinecontraction. However, there are numerous reports suggesting possible placental barriers thah protect the fetus from mostviral infections including those from human immunodeficiency viruses and human T cell leukemia viruses (HTLV).Basic scientists and clinicians should investigate the anti viral local immune response in decidual tissue that allows fetalsurvival as a successful allograft and which protects maternal tissue from excessive trophoblast invasion.

keyword

vertical viral infection, maternal immune response, placental barrier
ウイルス感染，母体免疫系，妊娠合併症，胎盤関門