原著

著者

根本　安人　　松田　哲也*　　松浦　雅人**　　本下　真衣***
大久保起延　　大久保博美　　鈴木　正泰　　鹿中　紀子
松島　英介***　　小島　卓也
日本大学医学部精神医学講座
*玉川大学学術研究所脳活動イメージングセンター
**東京医科歯科大学大学院保健衛生学研究科生命機能情報解析学分野
***東京医科歯科大学大学院心療緩和医療学分野

要旨

Abnormal exploratory eye movements have been studied as a biological marker for schizophrenia. Using fMRI, weinvestigated brain activations of 12 healthy and 8 schizophrenic subjects during performance of a visual exploration taskthat is similar to the responsive search score task to clarify the neural basis of the abnormal exploratory eye movement.Performance data, such as the number of eye movements, the reaction time, and the percentage of correct answers showedno significant differences between the two groups. Only the normal subjects showed activations at the bilateral thalamusand the left anterior medial frontal cortex during the visual exploration tasks. In contrast, only the schizophrenic subjectsshowed activations at the right anterior cingulate gyrus during the same tasks. The activation at the different locationsbetween the two groups, the left anterior medial frontal cortex in normal subjects and the right anterior cingulate gyrus inschizophrenia subjects, was explained by the feature of the visual tasks. Hypoactivation at the bilateral thalamus supportsa dysfunctional filtering theory of schizophrenia.

keyword

schizophrenia, exploratory eye movement, thalamus, anterior cingulate, medial frontal
統合失調症，探索眼球運動，視床，前帯状回，内側前頭葉